Project Grant R21CA303193
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $679,290 Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to The Regents of the University of California, San Francisco, effective April 1, 2026, through March 31, 2031. This award supports the development and translation of novel hyperpolarized (HP) carbon-13 dual-agent magnetic resonance imaging (MRI) technology designed to quantitatively assess prostate cancer aggressiveness and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $712,375 Project Grant to the University of California, Berkeley, effective April 1, 2026 through March 31, 2031, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). The grant supports development of the ADAPT PRO system, a digitally programmable radiofrequency (RF) imaging platform designed to enable Magnetic Resonance Imaging (MRI) of multiple nuclear isotopes beyond the standard hydrogen-1...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Grant Award Summary The National Cancer Institute awarded a $700,838 Project Grant to The Regents of the University of California, San Francisco under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for a five-year period beginning April 1, 2026. This award supports research to develop and optimize a Magnetic Resonance (MR) multi-tasking abdominal integrated imaging system (MT-AI2) capable of providing clinically accessible voxel-level liver functional assessment for...
- Federal Grant Award Summary The University of California, San Francisco received a $414,402 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded May 1, 2026, with completion targeted for April 30, 2028. This research initiative develops multi-modality computational modeling to improve glioblastoma radiation therapy targeting by integrating diffusion tensor imaging (DTI) and molecular biomarkers. The project delivers white matter...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $382,449 Project Grant to the University of California, Los Angeles under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 16, 2025, with completion targeted for June 30, 2027. This research project develops and validates advanced dual-nuclei magnetic resonance imaging (MRI) techniques to non-invasively differentiate between recurrent brain metastases (RBM) and radiation-induced necrosis (RN)...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a Project Grant totaling $593,557.00 under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) beginning March 18, 2026 and concluding February 28, 2031. The award supports research and development of novel magnetic resonance (MR) methods for real-time measurement and monitoring of treatment response to BPM31510, an emerging lipophilic tumor therapy composed of Coenzyme...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $677,787 to The Regents of the University of California, San Francisco on August 26, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award supports a five-year research initiative (through July 31, 2030) investigating AIRE-expressing tumor-associated macrophages (AIRE+ TAMs) as novel mediators of tumor immune evasion. The research aims to characterize the molecular and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $185,760.00 to The Regents of the University of California, San Francisco under the Cancer Research Manpower program (CFDA 93.398) on July 7, 2025. This Project Grant funds research aimed at enhancing treatment outcomes for metastatic castration-resistant prostate cancer (MCRPC) through the development of novel tumor-targeted combination therapy. The primary research deliverable involves creating a single...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $409,141 Project Grant to the University of California, Davis under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period June 1, 2026 through May 31, 2028. The project, titled "Perfusion CT for Liver Radioembolization," aims to develop and validate contrast-enhanced perfusion computed tomography (CT) imaging as an alternative diagnostic approach for treatment planning in selective...
The National Cancer Institute awarded The Regents of the University of California, San Francisco a $421,685 Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) with an award date of June 1, 2026, and completion date of May 31, 2028. The grant supports research to develop hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) as a predictive biomarker for immunotherapy response in cancer patients. This research addresses critical gaps in current treatment evaluation methods by enabling real-time metabolic monitoring that can distinguish between pseudoprogression (immune infiltration causing apparent tumor enlargement despite cancer cell death) and true treatment resistance, potentially allowing earlier detection of therapy failure and more timely therapeutic pivots for advanced cancer patients. The project leverages HP 13C MRI technology, which enhances 13C signal-to-noise ratios by greater than 104-fold to enable quantitative, nonradioactive metabolic imaging. This approach aims to overcome limitations of standard response evaluation criteria (RECIST and immune-response related criteria based on CT and MRI) that often prove insufficient in the immunotherapy setting due to extended evaluation periods (typically three months or longer) and inability to reliably distinguish disease progression from immune-mediated tumor enlargement. Successful validation of this metabolic imaging approach could provide oncologists with a rapid, quantitative tool to predict immunotherapy efficacy and inform treatment decisions for cancer patients with limited time and significant treatment-related toxicity concerns.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $421.7k | 5/27/26 |