Project Grant R21CA297395

Award Date 12/9/24
Completion Date 11/30/26
Dollars Obligated $206K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Birmingham, AL 35294, USA
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This $627,573 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to optimize radioligand therapy dosimetry and kidney biomarkers for alpha-emitter radiotherapy in neuroendocrine tumors. The key products and services to be delivered include: Developing a detailed understanding of the role of superoxide dismutation in tubular DNA repair following alpha-emitter radiotherapy Identifying optimal dosing regimens of the [212Pb]Pb-VMT-A-NET...
The National Cancer Institute (NCI) awarded a $644,034 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a nanoparticle-based drug delivery platform that uses radiation to control the release of chemotherapy payloads within irradiated tumor tissue. The project aims to expand the therapeutic window of chemoradiation by improving local disease control while mitigating...
The National Cancer Institute (NCI) awarded a $695,205 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, effective June 1, 2025 through May 31, 2030, will support early phase clinical trials of 211At-meta-astatobenzylguanidine (211At-MABG) for the treatment of neuroblastoma in children and advanced neuroendocrine cancers in adults....
This $644,622 Project Grant, awarded by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), aims to enhance the efficacy of radioligand therapy for metastatic castrate-resistant prostate cancer. The key products and services to be delivered include: Developing a novel method for bone marrow dosimetry by coupling macro/micro Monte Carlo modeling with imaging data on lesion and marrow distribution in spongiosa. Building predictive models to forecast absorbed...
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This Project Grant award of $662,516 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to evaluate how fractionated radiation affects the tumor microenvironment to influence passive drug delivery. The key research objectives are: Quantify how local radiation reshapes the tumor microenvironment to impact passive drug delivery in mouse and patient-derived cancer models, using in vivo imaging, multiplexed microscopy, and functional perturbations. Test whether...
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The National Cancer Institute (NCI) awarded a $205,621 Project Grant (CFDA 93.395 - Cancer Treatment Research) to the University of Alabama at Birmingham (UAB) to develop a novel nanobody framework with reduced kidney retention for use in targeted radiotherapy. The key products and services to be delivered under this 2-year grant, which began on December 9, 2024, include:

  1. Generating a new nanobody framework with over 90% reduction in kidney retention compared to existing immunization-derived nanobodies. This framework will serve as the basis for further development and testing.

  2. Exploring the ability to engraft complementarity determining regions from previously isolated nanobodies into the new framework to leverage existing binding capabilities.

  3. Designing the nanobodies to incorporate a sortase tag for rapid and site-specific conjugation to bifunctional chelators, enabling both imaging and therapeutic radionuclide incorporation.

  4. Conducting in vitro assessments of the radiolabeled nanobodies for affinity, specificity, and stability prior to in vivo PET imaging and radiotherapy studies.

Overall, this project aims to develop a novel nanobody platform that can improve the therapeutic index of targeted radiotherapy by addressing the limitations of existing targeting molecules.

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