Project Grant R44CA287485

Award Date 9/19/24
Completion Date 8/31/27
Dollars Obligated $792K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
New York, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $1,237,513 to The Washington University to develop a novel combination molecular radiotherapy approach for treating relapsed and refractory neuroblastoma, the most common extracranial solid cancer in children. The research aims to evaluate the efficacy and biological effects of two high linear energy transfer radiopharmaceuticals, 77Br-MBBG targeting the norepinephrine transporter and...
This $503,194 Project Grant award from the National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) supports research at Seattle Children's Hospital aimed at developing an innovative multispecific T cell engager (MTE) therapy to treat neuroblastoma and other pediatric solid tumors. The key products and services being delivered under this 2-year award include: 1) Determining the efficacy of the R2P3 MTE, which binds to the ROR1 and PD-L1 tumor targets as well as CD3 on T cells,...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $131,300 to Middle Tennessee State University to develop a novel dual inhibitor for the treatment of MYCN-amplified neuroblastoma. The key objectives are to: Identify the genes regulated by the N-MYC oncogene and its cofactors WDR5 and G9A, and determine how combined inhibition of these cofactors impacts N-MYC-dependent transcription. Pursue the identification and screening of potential...
The National Cancer Institute (NCI), under the federal Cancer Treatment Research program (CFDA 93.395), awarded a $695,205 Project Grant to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant supports early-phase clinical trials of 211At-meta-astatobenzylguanidine (211At-MABG) for the treatment of neuroblastoma in children and advanced neuroendocrine cancers in adults. The researchers aim to assess the safety and...
This $399,669 federal Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to establish the feasibility of commercializing a personalized and multi-targeted adoptive T cell therapy (ATCT) for glioblastoma (GBM), the most common and deadly primary brain tumor. The key products or services to be delivered under this grant include: Evaluating the ability of the applicant's Prussian blue nanoparticle-based photothermal therapy (PBNP-PTT) platform to...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides funding to develop high-quality chemical probes to functionally annotate the epigenetic effector "reader" domains within the Bromodomain PHD Finger Transcription Factor (BPTF) in neuroblastoma, an aggressive pediatric cancer. The $738,024 award, effective from January 1, 2025 to December 31, 2029, aims to optimize BPTF bromodomain and plant homeodomain (PHD)...
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This federal Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $792,367 to Nanopharmaceuticals LLC to develop a novel dual-targeting ligand, NP855, for the treatment of high-risk neuroblastoma. The key products and services to be delivered under this grant include:

  1. Scaled-up manufacturing and analytical evaluation of the NP855 drug substance to enable formulation of the drug product.
  2. In vitro and in vivo studies to confirm the efficacy of the scaled-up NP855 product, including assessments of its binding affinity to integrin αvβ3 and norepinephrine transporter, as well as anti-tumor and anti-angiogenic effects in neuroblastoma models.
  3. Nonclinical toxicology evaluations, including dose range-finding and repeated dose studies in rodent and non-rodent species, to establish the safety and toxicokinetics of NP855 in preparation for an Investigational New Drug (IND) application.

This award supports the development of a novel dual-targeting therapeutic for the management of high-risk neuroblastoma, a highly aggressive pediatric cancer with a poor prognosis. The funding period runs from Sep 2024 to Aug 2027.

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