This federal Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $696,447.00 to support research focused on developing novel imaging and targeted alpha particle therapy approaches for malignant mesothelioma. The award supports the University of Virginia as the prime recipient in: Evaluating a 203Pb-labeled antibody targeting the CD46 tumor antigen for SPECT imaging to detect mesothelioma across subtypes, including the hard-to-treat sarcomatoid subtype. Developing a 212Pb-labeled version of the same antibody for targeted alpha particle therapy and assessing its efficacy and tolerability in mesothelioma cell line and patient-derived xenograft models. The award includes sub-grants to the University of California, San Francisco for antibody engineering, characterization, and target analysis, as well as the University of Alabama at Birmingham for providing expertise on radionuclide pharmacokinetics and dosimetry calculations. The project aims to translate these targeted imaging and therapy approaches into future clinical trials for mesothelioma patients.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $696.4k | 12/27/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
GR105504SUB00001381S | The Regents Of The University Of California. San Francisco | Project Grant R01CA288612 | $326.7k | 4/23/25 | |
GR105405SUB00001387S | University Of Alabama At Birmingham | Project Grant R01CA288612 | $12.1k | 4/7/25 |