This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $235,620.00 to the Albert Einstein College of Medicine in Bronx, NY to develop and evaluate a novel transition state inhibitor, MTDIA, and improved MTDIA pro-drugs for preventing and treating inflammation-associated colorectal cancer. The research aims to determine the efficacy of these compounds in unique mouse models of sporadic colon tumors and rectal cancer driven by inflammation. The project will also investigate the effects of MTDIA and pro-drugs on elevating MTA, inflammation, apoptosis, and stem cell programming as potential mechanisms for tumor inhibition. This 2-year research effort builds on the institution's expertise in cancer biology and drug development to advance new therapeutic approaches for preventing and treating inflammation-linked colorectal cancers.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $235.6k | 12/11/24 |