The National Cancer Institute (NCI) awarded a $1,285,884 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the University of Houston System to develop clinical decision-support algorithms for designing patient-specific breast molds for tissue shaping in autologous breast reconstruction. The four-year study (August 2024 - July 2028) aims to improve the efficiency of autologous breast reconstruction, an important component of breast cancer rehabilitation,...
This Project Grant award, provided by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to develop a novel acellular scaffold for regenerating the nipple-areolar complex after mastectomy procedures. The $274,194 award to Novothelium, LLC, a small business located in San Antonio, Texas, will fund in vivo studies to investigate cellular infiltration, biocompatibility, and pigmentation of the acellular graft, with the goal...
This $544,475 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop an in vitro cancer metastasis model system using decellularized organ-specific tissue (biomatrices) to study organ-specific cancer metastasis. The University of Texas Southwestern Medical Center, the awardee, hypothesizes that the biomatrices can recapitulate the organ microenvironment and enable the growth of organ-specific tumor colonies, which can be used to investigate...
The National Cancer Institute (NCI) awarded a $556,684 Project Grant (CFDA 93.394 - Cancer Detection and Diagnosis Research) to the Palo Alto Veterans Institute for Research (PAVIR) to develop a bioengineered therapeutic device for the prevention of lymphedema. The objective is to optimize the structural and mechanical properties of a collagen conduit implant to promote lymphatic regeneration and normalize lymph flow, thereby preventing the onset of lymphedema in at-risk cancer patients. As a...
The U.S. National Cancer Institute (NCI) awarded a $450,000 Project Grant under the CFDA 93.396 Cancer Biology Research program to The Research Foundation for the State University of New York, doing business as Stony Brook University. The project, titled "Topological Methods for Breast Tissue Quantification," aims to develop advanced algorithms and analytical techniques using topological data analysis (TDA) to extract and interpret fine-grained structural information from breast...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $703,540.00 to Brigham & Women's Hospital Inc. to develop and optimize highly effective treatments for head and neck cancer using in situ implantable microdevices. The primary goals are to: Conduct a clinical study to validate the performance of the microdevice in predicting patients' clinical response to immunotherapy and chemotherapy for head and neck squamous cell...
This $895,779 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to advance the science of brain metastases from HER2-positive breast cancer. The key products and services to be delivered under this 7-year grant include: Understanding the fundamental biology and genetic risk factors of HER2-positive breast cancer metastases to the brain through patient tissue-based research. Developing real-time visualization techniques to track cancer cells and...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $519,210 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the Regents of the University of Michigan. The grant, effective September 1, 2024 through May 31, 2028, aims to develop nanoparticle strategies to reprogram innate immune cells and disrupt the metastatic niche in triple negative breast cancer. Key objectives include...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting the development of an optimized, off-the-shelf alternative to autologous fat grafting for soft tissue repair. The $293,983 award to Insoma Bio, Inc., a biotechnology company in Durham, North Carolina, will evaluate the combination of Insoma Bio's Fractomer tissue repair matrix and the Renuva adipose allograft material from MTF...
This National Science Foundation Project Grant of $299,785 will fund research into the integrated effects of mechanical and biochemical factors on breast tumor invasion and metastasis. Awarded on September 1, 2022 under the Engineering program (CFDA 47.041), the grant supports a collaborative research project led by the University of Michigan from September 1, 2022 through August 31, 2025. Specifically, the research team will develop quantitative imaging biosensors and tissue-engineered breast...