This Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) provides $179,988 to The Leland Stanford Junior University to support research aimed at modulating the human microbiome to enhance immune responses against cancer. The central hypothesis is that microbial functional features, rather than just compositional differences, underlie the impact of the gut microbiome on the efficacy of immune checkpoint blockade cancer immunotherapy. The research leverages advanced metagenomic analysis, genetic engineering of bacteria, and in vivo mouse studies to identify specific microbial genes and functions that can augment the tumor-fighting effects of cancer immunotherapy. By uncovering the mechanistic links between the microbiome and the immune system's response to tumors, this work seeks to inform personalized approaches to optimize immunotherapy outcomes. The project will be conducted at Stanford University from January 1, 2025 through December 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $180.0k | 12/18/24 |