This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $684,367 to the Baylor College of Medicine to conduct research aimed at identifying new predictors of response to immune checkpoint inhibitor (ICI) therapy in patients with non-small cell lung cancer (NSCLC). The key objectives are to: 1) Identify intratumoral microbiome profiles predictive of ICI response using whole-metagenome sequencing; 2) Characterize spatial immune signatures predictive of ICI response using single-cell imaging mass cytometry; and 3) Develop integrated predictive models of ICI response incorporating clinical, microbial, and immunological data. The project will leverage existing pre-treatment tumor samples and clinical data from over 500 NSCLC patients treated with ICIs across three independent cohorts. Relevant sub-awards include $97,630 to the Harvard T.H. Chan School of Public Health for data access and collaboration, and $62,849 to the H. Lee Moffitt Cancer Center and Research Institute for statistical support. This research aims to improve patient selection for ICI therapy by identifying novel microbiome and immune predictive biomarkers.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $684.4k | 7/16/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
P700001262S | H. Lee Moffitt Cancer Center And Research Institute Hospital, Inc. | Project Grant R01CA285882 | $62.8k | 11/25/24 | |
P700001260S | President And Fellows Of Harvard College | Project Grant R01CA285882 | $97.6k | 11/25/24 |