Project Grant R01CA285882

Award Date 8/1/24
Completion Date 7/31/29
Dollars Obligated $684K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
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The key objectives are to: 1) Identify intratumoral microbiome profiles predictive of ICI response using whole-metagenome sequencing; 2) Characterize spatial immune signatures predictive of ICI response using single-cell imaging mass cytometry; and 3) Develop integrated predictive models of ICI response incorporating clinical, microbial, and immunological data. The project will leverage existing pre-treatment tumor samples and clinical data from over 500 NSCLC patients treated with ICIs across three independent cohorts. Relevant sub-awards include $97,630 to the Harvard T.H. Chan School of Public Health for data access and collaboration, and $62,849 to the H. Lee Moffitt Cancer Center and Research Institute for statistical support. This research aims to improve patient selection for ICI therapy by identifying novel microbiome and immune predictive biomarkers.

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