Project Grant R21AT013576
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Florida $603,019 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to optimize novel REV-ERB agonist compounds for treatment of chronic inflammatory pain. The funded research develops high-affinity REV-ERB agonists with demonstrated in vivo...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Lowell $2.272 million on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to discover novel, non-opioid, non-addictive analgesics derived from marine microbial natural products. The award funds a phenotypic screening effort combining human induced pluripotent stem cell sensory neurons and glia cultured on multi-well microelectrode arrays to characterize sensory neuron...
- The National Center for Complementary and Integrative Health (NCCIH), within the Department of Health and Human Services National Institutes of Health, awarded Virginia Polytechnic Institute & State University $451,417 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to discover and develop millipede alkaloids as pain-management agents targeting sigma receptors. The project focuses on heterocyclic terpenoid alkaloids produced...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $387,000.00 to Florida Atlantic University to develop novel intranasal delivery cyclic peptide analgesics for pain management. The research aims to create new peptide-based pain medications that combine kappa-opioid receptor agonist activity with serotonin and/or norepinephrine delivery, with the goal of improving pain relief while minimizing...
- The National Institute of Neurological Disorders and Stroke awarded the University of Florida $187,317 on July 20, 2026, to characterize the endometriosis microbiome and metabolomic pain phenotype under the Drug Use and Addiction Research Programs (CFDA 93.279). The project stratifies individuals with endometriosis into treatment-responsive groups by identifying differences in microbial and NAD+ metabolomic patterns associated with differing pain characteristics, quality of life, psychological...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded The Pennsylvania State University $145,520 on October 3, 2025, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds research to identify novel analgesic compounds from ghost pipe (Monotropa uniflora), a North American medicinal plant historically used for pain management. The project...
- The University of Kentucky Research Foundation received a $355,514 Project Grant award from the National Center for Complementary and Integrative Health (CFDA 93.213 - Research and Training in Complementary and Integrative Health) on September 17, 2024. The grant funds a collaborative research project to isolate and evaluate bioactive compounds from Cameroonian plant extracts for their potential as novel, non-opioid analgesics targeting calcium homeostasis mechanisms, with a focus on the sigma 2...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health under the Department of Health and Human Services, awarded the University of Maryland, Baltimore $4.929 million on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a multi-omic, psychosocial, and environmental model of individual differences in pain and placebo responses. The project investigates chronic pain conditions, particularly...
- This $366,000 federal Project Grant award, titled "VALIDATION OF A NONOPIOID ANALGESIC PATHWAY IN HUMAN SENSORY GANGLIA AND SPINAL CORD," was issued on September 15, 2024 by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The award was granted to the University of Florida to conduct advanced biomedical research focused on transforming healthcare for military service members and the broader public. The research will explore innovative...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
The National Institutes of Health National Center for Complementary and Integrative Health awarded the University of Florida $422,125 on July 21, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to identify and characterize novel analgesic compounds derived from plant- and animal-associated microorganisms. The project uses a zebrafish-based model for nociceptive pain to screen microbial metabolites from bacteria and fungi for analgesic activity. Aim 1 isolates the active principle from microbial extracts with demonstrated pain-relieving properties. Aim 2 identifies the mechanism of action of lead compounds through in vitro assays with mammalian cells and in vivo neural recordings using zebrafish. The work addresses an urgent clinical need for improved pain therapeutics, leveraging the exceptional chemical diversity of small molecules produced by microorganisms as a source for new drug leads and molecular probes. The University of Florida Division of Sponsored Research is the recipient. Performance occurs in Gainesville, Florida. The period of performance extends from the award date through June 30, 2028. The project is led by a multidisciplinary team with expertise in natural products drug discovery and systems neuroscience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.1k | 7/23/26 |