Project Grant R21AT013863
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded The Pennsylvania State University $145,520 on October 3, 2025, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds research to identify novel analgesic compounds from ghost pipe (Monotropa uniflora), a North American medicinal plant historically used for pain management. The project...
- The University of Kentucky Research Foundation received a $355,514 Project Grant award from the National Center for Complementary and Integrative Health (CFDA 93.213 - Research and Training in Complementary and Integrative Health) on September 17, 2024. The grant funds a collaborative research project to isolate and evaluate bioactive compounds from Cameroonian plant extracts for their potential as novel, non-opioid analgesics targeting calcium homeostasis mechanisms, with a focus on the sigma 2...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded the University of Florida $422,125 on July 21, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to identify and characterize novel analgesic compounds derived from plant- and animal-associated microorganisms. The project uses a zebrafish-based model for nociceptive pain to screen microbial metabolites from bacteria and fungi for analgesic activity....
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded $439,500 to the University of California, San Diego on April 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds development of structural biology tools to enable high-resolution cryo-EM elucidation of type I polyketide synthases isolated directly from natural producer...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Virginia Polytechnic Institute & State University $733,233 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop novel nitroxoline analogs for oral treatment of drug-resistant Neisseria gonorrhoeae and Chlamydia. The project addresses the dual public health challenge posed by these sexually transmitted infections....
- The National Center for Complementary and Integrative Health (NCCIH), a component of the Department of Health and Human Services National Institutes of Health, awarded Pennsylvania State University $107,478 on August 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to support the Penn State Natural Products Pharmacology Training Program (PS-NPPTP). The program trains the next generation of natural products medicines researchers and educators....
- The National Center for Complementary and Integrative Health of the Department of Health and Human Services awarded Southern California University of Health Sciences $535,524 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to assess the quality and value of non-pharmacological therapies compared to prescription drug therapy for managing spinal pain in Medicare beneficiaries aged 65 and older. The research will use Medicare...
- The National Institute of Neurological Disorders and Stroke awarded Research Triangle Institute (RTI International) $230,562 on April 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop neuromedin receptor 2 (NMUR2) antagonists as novel analgesics for chronic pain treatment. The award funds the establishment of a comprehensive structure-activity relationship (SAR) for two chemical series of NMUR2 antagonists, with...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services National Institutes of Health, awarded $437,541 to Virginia Polytechnic Institute & State University on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antisense therapeutics targeting Clostridioides difficile infection. The research focuses on designing antisense oligomers, including peptide nucleic acids, to suppress...
- The National Center for Complementary and Integrative Health awarded the University of California Irvine $249,000 on August 10, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to investigate nutrition-based interventions for pain management in sickle cell disease. The project, titled "Nutrition-Based Interventions to Ameliorate Pain in Sickle Cell Disease," tests whether a nutrient- and omega-3 fatty acid-enriched diet can reduce...
The National Center for Complementary and Integrative Health (NCCIH), within the Department of Health and Human Services National Institutes of Health, awarded Virginia Polytechnic Institute & State University $451,417 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to discover and develop millipede alkaloids as pain-management agents targeting sigma receptors. The project focuses on heterocyclic terpenoid alkaloids produced by millipedes (subterclass Colobognatha) as novel alternatives to opioid analgesics for chronic and neuropathic pain. Virginia Tech's research team has identified ischnocybine A as a potent antagonist of sigma-1 receptors with selectivity over sigma-2 receptors, with preliminary characterization showing favorable central nervous system properties including microsomal stability and membrane permeability. The work encompasses chemical investigation of millipede defensive secretions, synthesis of analogs, and pharmacological evaluation toward clinical development of sigma receptor ligands for pain conditions. Performance takes place in Blacksburg, Virginia. The project period runs from the award date through June 30, 2028. This is a Project Grant, the assistance type used by NCCIH for research projects led by principal investigators at eligible institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.4k | 7/22/26 |