Project Grant R21AT013325
- This federal Project Grant award of $587,521 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research by the Regents of the University of Michigan to explore the molecular mechanisms and therapeutic potential of near-infrared light (NIR) in mitigating mitochondrial dysfunction and oxidative damage following traumatic brain injury (TBI). The research aims...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $367,261 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to the Regents of the University of Minnesota. This 2-year project aims to develop an experimentally-validated numerical simulation that couples a physiologically-realistic spreading depolarization (SD) model to a detailed glymphatic system model. The simulation...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $465,752 to the Regents of the University of Michigan - Dearborn to conduct research on understanding changes in cell chirality and cell-cell interactions within the neurovascular unit (NVU) after traumatic brain injury (TBI). The project aims to evaluate TBI-induced...
- The Regents of the University of Minnesota received a $325,450.00 Project Grant award on August 5, 2025 from the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative program (CFDA 93.372). The grant will fund the development of ultra-high-speed voltage imaging technology to record the neural activity of Purkinje cells in the cerebellum of awake, behaving mice. The...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $654,218 to the University of Maryland, Baltimore to support research on the mechanisms and intervention of cyclic GMP-AMP synthase (cGAS) signaling in traumatic brain injury (TBI). The research aims to investigate how the leakage of genomic and mitochondrial DNA into the brain after TBI...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,250 Project Grant under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 2-year grant will fund research using cutting-edge voltage imaging to examine how interactions between specific neuronal circuit elements in the hippocampus relate to the development of temporal lobe...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" provides $404,100.00 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to study the mechanisms of chronic blood-brain barrier dysfunction after traumatic brain injury (TBI). The research aims to identify a signaling pathway involving the...
- The University of Illinois, doing business as The Board of Trustees of the University of Illinois, received a $457,049 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders. The grant, awarded on Sep 15, 2023, will fund research to apply human in vitro models to understand the link between traumatic brain injury (TBI) and tau pathology in Alzheimer's disease and...
- This federal Project Grant award of $486,110 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support advanced research at the University of Minnesota. The project aims to use cutting-edge optical imaging techniques like three-photon imaging, two-photon optogenetics, and two-photon photothrombosis to precisely map neurovascular coupling - the link between...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...
The Regents of the University of Minnesota received a $391,215 Project Grant from the National Center for Complementary and Integrative Health (CFDA 93.213) to conduct research on "Mechanistic Underpinnings of Trigeminal Nerve Stimulation as a Therapeutic Approach to TBI." The project aims to utilize mouse experiments and numerical simulations to investigate how trigeminal nerve stimulation can reduce cerebral edema and improve functional outcomes in traumatic brain injury (TBI) patients. The central hypothesis is that trigeminal nerve stimulation enhances extracellular fluid transport through the glymphatic system, thereby removing excess fluid and improving neuroinflammation. This 2-year research project is intended to provide mechanistic insights to support the translation of trigeminal nerve stimulation therapies for TBI.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $391.2k | 8/26/25 |