Project Grant R21AR086401
- The National Institute of Neurological Disorders and Stroke, a component of the National Institutes of Health within the Department of Health and Human Services, awarded $3.686 million to the Trustees of Indiana University on August 15, 2026, to investigate CAMKK2-mediated pain mechanisms in post-traumatic osteoarthritis. The project, funded under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research designed to develop non-opioid therapies for osteoarthritis-related...
- The National Institute of Neurological Disorders and Stroke awarded the University of Pittsburgh $9.799 million on September 19, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to elucidate biopsychosocial mechanisms underlying inter-individual differences in movement-evoked pain and functional impairment in knee osteoarthritis. The research uses concurrent ambulatory brain imaging and gait biomechanics during the 6-minute walk test to identify overlapping and distinct...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $1.95 million Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 10, 2025, with an ultimate completion date of August 31, 2028. This research project investigates cellular stress mechanisms in osteoarthritis (OA) by examining the IRE1α-XBP1-NUPR1...
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $2,265,261 on July 15, 2026, under the Aging Research program (CFDA 93.866) to investigate integrin signaling mechanisms in osteoarthritis progression. The award funds basic research examining how α5β1 integrin receptor activation by fibronectin matrix degradation products initiates pathologic cellular signaling cascades that drive chronic, non-healing inflammation and progressive cartilage destruction in...
- This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of North Carolina at Chapel Hill a $222,758 Project Grant on August 7, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research through July 31, 2027. The award funds a comprehensive neuroscience investigation aimed at delineating how different molecularly defined dorsal root ganglia (DRG) neuron types contribute to pain representation...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3,503,160 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate glial-neuronal crosstalk in neuropathic pain and diabetes. The research examines how mitochondrial transfer from satellite glial cells to sensory neurons protects against neuropathic pain and how dysfunction of this process contributes to diabetic peripheral neuropathy. The project employs two specific...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $3,320,159 to North Carolina State University to develop and validate a comprehensive battery of tests to assess emotional and cognitive function in dogs with naturally occurring osteoarthritis pain. The goal is to establish a clinically-relevant animal model for evaluating the biopsychosocial impacts of chronic musculoskeletal...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Duke University $1,054,899 on September 19, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to conduct research on JAK-specific signaling in post-traumatic osteoarthritis-associated joint degeneration and pain. Duke University's Office of Research Administration will identify which Janus kinases (JAK1, JAK2, and/or TYK2) mediate both cartilage catabolism and nociceptive...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
The National Institute of Neurological Disorders and Stroke awarded Wake Forest University Health Sciences $426,250 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate sensory neuron-fibroblast crosstalk in knee osteoarthritis. The research examines how sensory neuron-derived calcitonin gene-related peptide (CGRP) regulates inflammation and fibrosis within joint tissue, contributing to osteoarthritis pain and disease progression. The work focuses on understanding cell type-specific mechanisms by which CGRP influences both pain and disease pathology, with particular attention to sexual dimorphism in CGRP's role in nociceptive processing across osteoarthritis models. Prior research by the investigative team demonstrated that CGRP deficiency reduced knee hyperalgesia development in female but not male mice following Complete Freund's Adjuvant-induced knee inflammation, with reductions associated with decreased knee edema, macrophage infiltration, and fibrosis. Performance occurs in Winston-Salem, North Carolina, with a period of performance from September 1, 2026, through August 31, 2028. The award is structured as a Project Grant, the standard NIH R21 mechanism supporting exploratory and developmental research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.3k | 8/14/26 |