Project Grant R01AR085335
Award Date
9/18/24
Completion Date
8/31/27
Dollars Obligated
$3.3M
Funding Federal Agency
National Institute of Neurological Disorders and Stroke
Awarding Federal Agency
National Insititue of Arthritis and Musculoskeletal and Skin Diseases
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Raleigh, NC 27695, USA
Similar Awards
This $2,569,851 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate how the PD-L1/PD-1 immune checkpoint pathway controls physiological and pathological pain, as well as opioid analgesia, through neuronal, immune, and glial mechanisms. The project aims to validate the actions of PD-L1 and the checkpoint inhibitor nivolumab on neuroinflammation and...
The Project Grant award R61NS133704, totaling $1,846,202.00, was provided by the National Institute of Neurological Disorders and Stroke under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to Duke University. The primary objective is to develop potent, selective, and peripherally-restricted antagonists of the adrenergic receptor beta-3 (ADRB3) for the treatment of chronic primary pain conditions affecting over 100 million people. This will involve: 1) developing novel ADRB3...
The University of North Carolina at Chapel Hill was awarded a $9,275,866 Cooperative Agreement by the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to develop small molecule drugs that engage a specific G protein-coupled receptor (GPCR) in the amygdala, which could provide a safer alternative to opioid-based pain relief by reducing the unpleasant perception of pain without the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $9,237,770 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University to conduct the "IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain After Surgery" research project. The goal is to gain integrated mechanistic insights into peripheral and central biological processes that contribute to chronic postsurgical pain...
This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
This $4,572,599 Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to elucidate the neural mechanisms by which colored light can produce analgesia (pain relief) for chronic musculoskeletal pain conditions, including fibromyalgia. The research team, led by the University of North Carolina at Chapel Hill, will (1) identify color-sensitive retinal ganglion cells that...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $2,884,007 to the University of California, San Diego (UCSD) to investigate mechanisms of intra- and inter-individual pain variability in patients with comorbid chronic low back pain (CLBP) and major depressive disorder (MDD). The research aims to generate individualized prediction models of momentary pain intensity using ecological momentary...
The National Institute on Drug Abuse (NIDA) awarded a $154,568 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University in St. Louis. The grant, titled "Investigating the Role of Dorsal Raphe Nucleus Enkephalin Neurons in Motivational and Affective Behaviors During Chronic Pain", aims to determine the contribution of endogenous opioids in the dorsal raphe nucleus to motivational and affective dysregulation during chronic pain. The...
This $150,000 Project Grant award under the Trans-NIH Research Support program (CFDA 93.310) from the National Institutes of Health aims to develop an Internet of Things system for synchronous physiological monitoring of humans and animals involved in animal-assisted interventions (AAIs). The project, led by North Carolina State University, will create wearable sensors to gather real-time physiological data from both patients and therapy dogs during AAI sessions. This will enable the research...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $441,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Duquesne University of the Holy Spirit. The purpose of this 3-year grant, beginning September 2023, is to utilize laboratory data and computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain. Specifically, the project aims to build a proof-of-concept 3-D...