This $143,949 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research aimed at defining how antibiotic-mediated gut dysbiosis and loss of certain short-chain fatty acid (SCFA)-producing bacteria alter intestinal and joint inflammatory responses. The 5-year project, led by Fang Roseanne Zhao, M.D., Ph.D. at Washington University, will use...
This $376,894 Project Grant, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports a study on chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD). The objectives are to define SJIA-LD, characterize its clinical progression, and validate surrogate biomarkers and patient-reported outcomes to accelerate future research. The 4-year study will...
This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $224,070 to the Regents of the University of Minnesota to study the cellular communication pathways between immune cells and stromal cells that contribute to autoimmune valvular carditis. The research aims to define the specific roles of fibroblasts, macrophages, and B cells in perpetuating inflammation and fibrosis in...
This Project Grant award of $167,076 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into understanding the transition from Lyme arthritis (LA) to antibiotic-refractory Lyme arthritis (ARLA). The objective is to determine the role of resident synovial macrophages in the joint space during B. burgdorferi infection and the development of ARLA. Key...
This federal Project Grant award, valued at $828,682 and awarded on September 24, 2024, supports research into population-based outcomes for rheumatoid arthritis (RA) in rural health settings. The funding is provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to investigate the challenges rural residents face in timely RA diagnosis and treatment...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $459,250 to Cedars-Sinai Medical Center to conduct research on the mechanisms of fibroblast-like synoviocyte (FLS) transmigration through endothelial cell (EC) layers in rheumatoid arthritis (RA). The key objectives are to validate a pathway connecting FLS transmigration with EC-mediated inflammation using RA synovial...
This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $664,933 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to investigate cellular and molecular mechanisms of IL-17A in the pathogenesis of psoriatic arthritis. The research aims to develop a novel animal model to define the early cellular and molecular pathways that drive...
This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of reverse transendothelial migration of neutrophils in inflammation resolution. The $366,797 award, with a project period from Sep 24, 2024 to Aug 31, 2026, aims to provide new insights into the mechanisms by which certain inflammatory mediators,...