The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $172,700 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of California, Irvine (UC Irvine) to develop a novel therapeutic approach for improving angiogenesis and wound healing. The project aims to deliver apoptotic neutrophils within a degradable hydrogel scaffold to stimulate macrophages and promote their angiogenic signaling and tissue repair without...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $404,140 to Cedars-Sinai Medical Center to investigate the role of the NLRP10 protein in regulating wound healing in cutaneous leishmaniasis. The research aims to identify the mechanisms by which NLRP10 mitigates fibroblast senescence and aids the wound repair response in the presence of...
This $205,000 project grant from the National Institutes of Health's National Institute on Aging will fund research into the pathomechanics of diabetic foot ulcers at The University of Texas Southwestern Medical Center over a 12-month period. The research aims to identify more accurate markers and marker combinations for foot ulceration risk in patients with diabetic neuropathy and a history of prior ulcers. Using specialized equipment, the study will quantify two primary ulcer-causing...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $257,310.00 to the University of Illinois to investigate the role of extracellular vesicles in mediating communication between endothelial cells and fibroblasts in the process of skin wound healing. The research aims to determine how fibroblast phenotypes are altered by...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of the epidermal integrin A3β1 in age-related declines in cutaneous wound healing. The $216,205 award to Albany Medical College aims to determine how waning A3β1 function in aging skin contributes to impaired wound re-epithelialization and reduced immune...
This $616,256 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports the development and pre-clinical validation of an "intelligent biorobot" for the regenerative rehabilitation of volumetric muscle loss (VML) injuries. The key objectives are to: Develop and optimize a cell-laden biorobot that mimics skeletal muscle properties, generates...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,025 to the University of Miami to investigate the role of Langerhans cells in wound healing, itch, and pain following burn injuries. The research aims to advance understanding of the molecular mechanisms behind these conditions and explore innovative treatment approaches by targeting specific Langerhans cell...
The National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, awarded a $176,840 Project Grant to the Rochester Institute of Technology (RIT) to develop a predictive mathematical model for obesity-induced type 2 diabetes mellitus (T2DM) and chronic wound healing. The goal is to create a model that realistically represents the key physiological factors correlated with the high prevalence of T1/T2 diabetes and impaired wound...
The National Institute of General Medical Sciences (NIGMS) awarded a $368,235 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of New Hampshire (UNH) to establish an integrated bioengineering framework for understanding how the synergistic effects of soluble and bound factors in biomaterials influence cell signaling and modulate cell function to promote chronic wound angiogenesis and healing. The project aims to develop an in vitro microfluidic...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $361,650 to Boston University Medical Campus to elucidate the mechanisms responsible for the sustained impairment of lymphatic vessel contractility and lymph flow following bacterial skin and soft tissue infections. The research aims to develop targeted interventions that can restore...