This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $404,140 to Cedars-Sinai Medical Center to investigate the role of the NLRP10 protein in regulating wound healing in cutaneous leishmaniasis. The research aims to identify the mechanisms by which NLRP10 mitigates fibroblast senescence and aids the wound repair response in the presence of the Leishmania parasite. The project will utilize a mouse model to define the contribution of cellular senescence to wound healing and determine how NLRP10 regulates this process. This research seeks to inform the development of novel therapeutic targets to accelerate cutaneous wound healing in leishmaniasis and potentially other pathologies. The award period spans from September 2023 through September 2025.
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