Project Grant R21AI199648
- Grant Award Summary Oregon Health & Science University received a $429,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 1, 2026, with a completion date of March 31, 2028. The project, titled "Novel Genetic Approaches to Elucidate Critical Signaling Pathways in Leishmania donovani," will deliver research services focused on identifying essential signaling...
- Federal Grant Award Summary Oregon Health & Science University received a $442,758 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 9, 2026, with completion targeted for January 31, 2028. The project, "Identifying Drug Targets in M. abscessus Through the Application of Fluorescent Probes," aims to elucidate the mechanistic basis of dual B-lactam...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $195,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 6, 2026, with completion targeted for January 31, 2028. The grant funds investigative research examining the intersection of sphingolipid metabolism and innate antiviral immunity, specifically addressing how Type I interferon...
- Federal Grant Award Summary Oregon State University received a $392,747 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 17, 2025, with completion targeted for June 30, 2027. The grant supports research into the biosynthesis and self-resistance mechanisms of kibdelomycin, a natural product antibiotic candidate with a novel binding motif to DNA gyrase. The research...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $482,625 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 1, 2026 through January 31, 2028. The award funds preclinical research to develop and evaluate long-acting antiretroviral therapy (LA-ART) as a therapeutic alternative to daily antiretroviral treatment regimens in simian...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $622,130 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 21, 2025, with a completion date of July 31, 2030. The grant funds research investigating bacterial manipulation of atypical ubiquitin signaling, a post-translational modification system that pathogenic bacteria exploit to hijack...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $429,992 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 1, 2025, through August 31, 2028. The research project targets T follicular helper (TFH) cell differentiation to enhance antibody responses in infant rhesus macaques following simian-human immunodeficiency virus...
- Federal Project Grant Award Summary Harvard Medical School received a $570,760 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 1, 2025 through August 31, 2030. The award funds research into the mechanistic and structural features of intraflagellar transport (IFT) in Leishmania parasites, which cause leishmaniasis and related diseases affecting millions...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $3.3 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 21, 2025, with a completion date of June 30, 2029. This grant supports multimodal positron emission tomography (PET) immunoimaging research designed to directly visualize HIV-1 persistence in vivo and identify early tissue foci...
- Federal Project Grant Award Summary Oregon State University received a $408,375 Project Grant award on July 14, 2025, from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on phage-antibiotic combination therapies for treating Mycobacterium abscessus (MAB) infections. The research deliverables focus on identifying and characterizing MAB surface targets involved in phage resistance mechanisms and...
Oregon Health & Science University (OHSU) received a $234,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 1, 2026 through April 30, 2028. The award supports research leveraging inducible open reading frame (ORF) screens to elucidate novel mechanisms of antileishmanial drug resistance. The research project aims to address critical gaps in understanding miltefosine resistance—the only orally available therapeutic for leishmaniasis—by utilizing advanced functional genomic tools, including a newly developed genome-scale, barcoded inducible overexpression library covering approximately 8,000 Leishmania donovani genes (the LdORFeome). The primary deliverables include scientific investigation into post-transcriptional regulation as an underexplored mechanism of drug resistance in kinetoplastid parasites, building upon the identification of ZC3H18, an RNA-binding protein validated as a novel resistance factor. The research will define molecular pathways regulated by Leishmania ZC3H18 to understand miltefosine resistance mechanisms, generating scientific knowledge intended to inform development of more effective therapeutic interventions and combat increasing treatment failures in leishmaniasis management.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $234.0k | 5/1/26 |