Project Grant R01AI184933
- This federal Project Grant award of $408,375.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Oregon State University (OSU). The award will fund research to deepen the understanding of phage biology and its interaction with Mycobacterium abscessus (MAB) bacteria, a clinically important pathogen associated with high morbidity and fatality rates. The goal is to apply this knowledge to...
- This $430,375.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on a novel inter-membrane lipid signaling mechanism in Gram-negative bacteria like E. coli and Pseudomonas aeruginosa. The research aims to elucidate how these bacteria can sense and respond to deficiencies in their outer membrane lipopolysaccharide (LPS) content, a critical component for...
- This $420,553 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to develop a single-cell technique that will measure the translation rate and transcriptome of thousands of individual bacterial cells, with a focus on understanding antibiotic tolerance in Staphylococcus aureus during chronic infections. The research will explore the heterogeneity in...
- The Project Grant award of $197,646 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to enhance the function of bacteriophages (viruses that attack bacteria) as a potential treatment for antimicrobial resistant bacterial infections. The award recipient, the University of California, San Diego (UCSD), will conduct experimental evolution studies to identify genetic...
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $569,210 to the University of Colorado Boulder to conduct research on the "Mechanisms of Lipid A Modification Impacting Antimicrobial Resistance". The key focus is on understanding how certain gram-negative pathogens modify their lipid A structures to develop resistance against cationic antimicrobial...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research grant program (CFDA 93.855), provides $463,676 to the University of Maryland, Baltimore for research to enhance the understanding of Fc-mediated effector functions in the context of infectious diseases. The project aims to dissect the mechanisms underpinning Fc-mediated effector functions, with a focus on antibody interactions with a...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, is supporting research to investigate the role of the protein synaptopodin during bacterial infection by Shigella flexneri. The $2,637,034 award to the University of Colorado-Denver aims to examine how synaptopodin contributes to the spread of S. flexneri and other intracellular pathogens between host cells. The research...
- This $481,250 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant will fund the development of new antimicrobial small molecule compounds that recruit the immune system to target bacteria. Key activities include the biochemical, biophysical, and cell biology characterization of these chimeric molecules formed by joining bacterial binding agents with...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
This federal Project Grant award, valued at $622,130.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate how bacterial pathogens manipulate atypical ubiquitin signaling pathways within host cells. The research aims to elucidate the molecular mechanisms by which specific bacterial effector proteins upregulate or downregulate Lys6-linked polyubiquitin signals, which may play a central role in host-pathogen interactions. The project will examine the specificity and functions of Lys6 polyubiquitin signaling, as well as the roles of bacterial E3 ligases that modulate this atypical ubiquitin signal during the course of infection. The award was made to Oregon Health & Science University, a prominent academic medical center and research institution, and the project is scheduled for completion by July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $622.1k | 8/21/25 |