Project Grant R21AI199320
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $431,750 Project Grant to the University of California, Irvine under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 1, 2025 through July 31, 2027. The research project focuses on developing and validating new complementation tools and conditional expression methods to enhance genetic approaches for studying Chlamydia trachomatis virulence determinants....
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia a Project Grant of $450,766 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, with completion targeted for July 31, 2027. This research initiative aims to characterize how Chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections, remodels inter-organelle communication within host cells to create a...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia a $717,952 Project Grant on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a five-year research initiative through January 31, 2031. The award funds investigator-initiated biomedical research focused on elucidating the mechanisms by which Chlamydia trachomatis acquires and maintains lipids within its...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $417,845 to the University of Nebraska Medical Center under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 9, 2025, for a project period extending through June 30, 2027. The award supports research to identify novel immune determinants influencing Staphylococcus aureus biofilm infection using Collaborative Cross (CC) mouse lines. The research addresses gaps in...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $899,850 to the Whitehead Institute for Biomedical Research under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 20, 2026, for a project concluding January 31, 2031. This Project Grant funds investigator-initiated biomedical research aimed at elucidating the molecular mechanisms by which apicomplexan parasites recognize and invade host cells. The research will...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $417,845 to the University of Nebraska Medical Center under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period from August 1, 2025, through July 31, 2027. The award supports the development and adaptation of an innovative in vitro organotypic human skin model designed to enable tick feeding and study the transmission and colonization of Borrelia...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts a $412,581 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. This research initiative focuses on investigating specialized mitochondrial deoxyribonucleic acid (DNA) polymerases in African trypanosomes to advance understanding of kinetoplast DNA (kDNA) replication mechanisms....
- Federal Grant Award Summary Oklahoma State University received a $145,745 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2027. The award supports research to elucidate the mechanisms by which Chlamydia trachomatis modulates host inflammasome activation, addressing a critical knowledge gap in understanding chlamydial pathogenesis. The...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $449,578 Project Grant to the University of California, San Diego under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 1, 2026, with a completion date of January 31, 2031. This research initiative investigates the role of lytic polysaccharide monooxygenases (LPMOs), specifically chitin-binding protein D (CBPD), in the pathogenesis and immunogenicity of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $440,000 in Project Grant funding under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Texas Medical Branch at Galveston, effective July 3, 2025, through June 30, 2027. This award supports research to determine the function and mechanism of long non-coding RNA CHAST in Trypanosoma cruzi infection and dissemination, which causes Chagas disease. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded $417,845 to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award was obligated on June 2, 2026, with a project completion date of May 31, 2028. The research project investigates post-translational modulation of host purine biosynthetic enzymes by Chlamydia trachomatis (CTR), an obligate intracellular bacterium. The study addresses a novel mechanism of nutritional immunity by examining how CTR exploits and modulates the host cell's guanosine triphosphate (GTP) biosynthesis pathway, specifically focusing on the enzyme inosine monophosphate dehydrogenase 2 (IMPDH2) and its filamentation dynamics as a regulatory mechanism. The research will advance scientific understanding of host-pathogen interactions and CTR's metabolic dependence on host cells, with potential implications for developing therapeutic interventions that target this vulnerability. The project contributes to NIAID's broader mission of supporting investigator-initiated biomedical research into infectious diseases and related immunological mechanisms, with expected outcomes including new scientific knowledge regarding pathogenic mechanisms and potential therapeutic candidates for improving public health outcomes related to chlamydial infections.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $417.8k | 6/3/26 |