This $145,745 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Oklahoma State University to investigate how the Chlamydia trachomatis bacterium, the leading cause of sexually transmitted infections worldwide, modulates the host's immune response and inflammasome activation. The research aims to elucidate the mechanism by which a specific Chlamydia protein, CT226, interacts with host proteins LRRFIP1 and FLII to regulate inflammasome activation and IL-1beta secretion during Chlamydia infection. The project will utilize innovative genetic tools and transformation methods, including a CT226 deletion mutant strain, to assess the role of inflammasome activation on Chlamydia replication, infectivity, and intracellular survival. This work seeks to address a critical knowledge gap in understanding how Chlamydia modulates the host immune response, which is crucial for developing effective interventions against this prevalent infectious disease.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $145.7k | 7/23/25 |