Project Grant R21AI199180
- Federal Project Grant Award Summary The University of Colorado-Denver received a $429,000 Project Grant award dated February 25, 2026, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project, titled "Understanding the Contributions of MAIT Cells in Colitis," extends through January 31, 2028, and focuses on investigating mucosal-associated invariant T (MAIT) cell biology in...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Colorado-Denver a $2,637,034 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 8, 2025, with completion targeted for July 31, 2029. This award funds biomedical research investigating the molecular mechanisms by which the actin-binding protein synaptopodin facilitates intracellular bacterial spread,...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Colorado-Denver a Project Grant of $186,953 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 13, 2026, with completion targeted for January 31, 2028. This grant supports basic biomedical research investigating the protective mechanisms of the airway microbiome against Staphylococcus aureus infection. The research focuses on identifying...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Colorado-Denver a $412,422 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the regulatory role of immunoglobulin A (IgA) antibodies in controlling Candida glabrata colonization within the intestinal microbiome. The two-year research project, which commenced February 1, 2026 and concludes January 31, 2028, will...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $234,000 to The Regents of the University of Colorado-Denver on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project, titled "Characterizing the Phosphorylation Profile of CD79A/B in B Cells at Rest and Following Antigen Receptor Stimulation," will be conducted in Aurora, Colorado, with a completion date of May...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $763,102 to The Regents of the University of Colorado (University of Colorado-Denver) on May 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The five-year research initiative, scheduled for completion on April 30, 2031, will be conducted in Aurora, Colorado, and focuses on investigating novel roles of mucosal tissue eosinophils in the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $766,730 to The Regents of the University of Colorado, performing as University of Colorado-Denver, under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning February 20, 2026, and extending through January 31, 2031. This Project Grant supports research investigating Staphylococcus hominis bacteriocins as protective agents against skin pathogens, with...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $225,953.00 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of Colorado, doing business as University of Colorado-Denver, effective July 22, 2025, with a completion date of June 30, 2027. The award funds fundamental immunological research focused on characterizing xenoglycan-reactive B cells—B cell populations that...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Colorado-Denver $2.73 million under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a four-year Project Grant effective September 4, 2025, through August 31, 2029. This award supports investigator-initiated biomedical research examining the mechanisms by which phage-salmonella interactions function during oxidative stress conditions. The research addresses...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Colorado-Denver a Project Grant of $234,000 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 23, 2026, with a completion date of March 31, 2028. This award funds research to dissect the transcriptional control of human mucosal-associated invariant T (MAIT) cells, focusing on the roles of transcription factors PLZF and Helios in governing cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $429,000 Project Grant to The Regents of the University of Colorado (University of Colorado-Denver) on June 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports a 24-month research initiative (through May 31, 2028) to develop engineered enterococcal bacteriophages as therapeutic agents for inflammatory bowel disease (IBD). The project delivers two primary research products: (1) engineered phages expressing immunomodulatory payloads such as anti-inflammatory cytokines and cytokine inhibitors validated through in vitro studies, and (2) preclinical evaluation of these engineered phages in murine IBD models to assess in vivo therapeutic efficacy, immune modulation, disease progression, and reduction of enterococcal burden. This research addresses a critical gap in IBD treatment by integrating targeted pathogen elimination with direct immunomodulation, offering a novel therapeutic approach that restores microbiota balance while reducing intestinal inflammation. The work is performed in Aurora, Colorado, and generates scientific knowledge intended to inform the development of inflammation-reducing therapies applicable to human IBD patients, aligning with NIAID's mission to support investigator-initiated biomedical research addressing infectious diseases and immunologic disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 6/8/26 |