Federal Grant Award Summary

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $234,000 to The Regents of the University of Colorado-Denver on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project, titled "Characterizing the Phosphorylation Profile of CD79A/B in B Cells at Rest and Following Antigen Receptor Stimulation," will be conducted in Aurora, Colorado, with a completion date of May 31, 2028. This award supports basic immunological research aimed at advancing understanding of B cell signaling mechanisms critical to vaccine-induced immunity and infectious disease response.

The research deliverables focus on characterizing how differential phosphorylation patterns of CD79A and CD79B proteins influence B cell activation and signaling properties. The project will systematically evaluate how various combinations of phosphorylated residues on these B cell receptor signaling components contribute to both activating and inhibitory signaling pathways. By elucidating these phosphorylation profiles at baseline and following antigen receptor stimulation, the research will generate fundamental scientific knowledge regarding B cell function and receptor signaling that has implications for understanding protective immunity in vaccination and infection, as well as pathological states such as autoimmunity.