Project Grant R21AI199177
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $452,835 Project Grant to the University of Pittsburgh under the Allergy and Infectious Diseases Research program (CFDA 93.855) with an award date of February 2, 2026, and completion date of January 31, 2028. This research initiative, titled "Reversing Graft Rejection by Targeting Innate Immune Memory with Novel Nanobiologics," focuses on developing innovative therapeutic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $4.34 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 13, 2025, with performance completion scheduled for May 31, 2030. This award funds a prospective cohort study examining the effects of vaccination on acute and post-acute respiratory viral infection (RVI) outcomes in solid organ transplant recipients...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $427,625 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Maryland, Baltimore, effective August 1, 2025, through July 31, 2027. This award funds basic biomedical research investigating CD27-mediated immune suppression mechanisms in hematopoietic stem and progenitor cells (HSPCs), innate immune cells, and non-hematopoietic cells. The...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $765,422 on April 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct systematic research on antigen diversification mechanisms in Trypanosoma brucei. The research will be performed in Baltimore, Maryland, with an ultimate completion date of March 31, 2031. The study addresses how this parasitic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $3.15 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 19, 2025, with completion targeted for August 31, 2029. The award supports fundamental research investigating macrophage senescence as a driver of granuloma failure and progression to necrosis in tuberculosis (TB) and TB/HIV co-infection. The research...
- Federal Project Grant Award Summary Emory University received a $100,228 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of September 30, 2026 and completion date of March 31, 2029. This research grant supports investigator-initiated biomedical research examining the regulation of alloreactive CD8+ memory T cells by T cell immunoreceptor with immunoglobulin domains...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $147,486 Project Grant effective September 21, 2025, through April 30, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports investigator-initiated research aimed at identifying metabolic targets to reinvigorate exhausted CD8+ T cells, which become dysfunctional following prolonged antigen exposure and exhibit poor...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $1,031,754 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 2, 2025, with a completion date of August 31, 2030. This award funds research to develop clinically relevant pharmacologic and immunomodulatory strategies for achieving long-term survival of kidney xenografts in primates. The research builds upon recent...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $462,000 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and optimize FAB-fragment drug conjugates (FDCs) as targeted immunosuppressive delivery systems for organ transplant applications. The project, which commenced February 4, 2026 and concludes January 31, 2028, will design and characterize an...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $155,227 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 9, 2025, with completion scheduled for May 31, 2027. The grant supports proof-of-concept research on an unconventional treatment regimen for Mycobacterium abscessus (MAB) chronic lung disease, a rapidly progressive non-tuberculous...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $254,529 Project Grant to The Johns Hopkins University on May 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop B-TOL, a multifunctional fusion protein biologic designed to regulate transplant rejection. The research, to be conducted in Baltimore, Maryland through April 30, 2028, addresses critical limitations in solid organ transplantation by combining anti-CD154 (cluster of differentiation 154) blockade with immunomodulatory moieties into a single recombinant therapeutic. This innovative approach aims to synergistically suppress pathogenic effector T cell differentiation while promoting conversion to regulatory T cells (Tregs), potentially reducing the need for lifelong immunosuppression and mitigating chronic rejection risks that currently limit transplantation outcomes. The funded research employs a multidisciplinary methodology integrating protein engineering, immunological characterization, and preclinical validation. Specific deliverables include profiling and functional characterization of Treg induced by different B-TOL construct candidates to identify optimal architecture, assessment of therapeutic efficacy using stringent mouse skin transplant models with fate-tracking of alloreactive T cells, and pharmacokinetic studies to inform clinical translation. This high-risk, high-reward project represents exploratory research intended to establish whether this unified biologic approach outperforms conventional multi-component immunosuppressive interventions for transplant tolerance induction.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $254.5k | 5/5/26 |