Project Grant R21AI197150
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $762,847 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the contribution of Type III interferons to the pathogenesis of Staphylococcus aureus infection. The research examines how Type III interferon signaling influences S. aureus pneumonia pathogenesis and bacterial clearance from the airway. The work includes investigation...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $571,412 to the University of Maryland, College Park on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the regulation of bacterial physiology and infections through linear diribonucleotides and RNA degradation. The project will characterize how diribonucleases and triribonucleases bind their respective...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $155,500 on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate heterogeneity in Staphylococcus aureus virulence factor activity within neutrophils and its impact on bacterial survival and host-pathogen interactions. The research examines how an isogenic population of S. aureus generates bacteria with divergent outcomes upon interaction with...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $813,248 on August 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of neutrophils in tuberculosis pathogenesis and post-TB lung disease. The research, conducted at the Newark, New Jersey location and extending through July 31, 2031, defines how early neutrophil recruitment, activation, and metabolic reprogramming regulate TB...
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland Baltimore County $421,242 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate bacterial ferrous iron sensing mechanisms in Pseudomonas aeruginosa via the BqsRS two-component signal transduction system. The research addresses the structure, selectivity, and mechanism by which P. aeruginosa—an antibiotic-resistant opportunistic pathogen responsible...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $482,071 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on copper homeostasis in fungal pathogenesis. The research uses Cryptococcus neoformans as a model system to explore how copper availability influences fungal survival during infection. The work examines cellular adaptations as this opportunistic pathogen transitions between high copper...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $647,356 on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of GPR132 in regulating CD8 T cell responses during infection and cancer. The research aims to determine how GPR132, a G protein–coupled receptor that detects oxidized endogenous and microbial lipids, regulates CD8 T cell expansion and memory differentiation. The...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $780,615 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on immune signaling and antibacterial defenses controlled by mycobacterial PE/PPE proteins. The research addresses mechanisms by which Mycobacterium tuberculosis manipulates host cell biology to establish infection. MTB secretes over 100 proteins that block macrophage...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $235,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize mechanisms of foam cell formation in tuberculosis and cryptococcosis infections. The recipient, operating as RBHS-School of Nursing, will conduct comparative analysis of pathogen-associated molecular patterns (PAMPs) and macrophage pattern recognition receptors (PRRs)...
- The National Institute of Allergy and Infectious Diseases awarded Boston Children's Hospital $800,557 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how the pathogen Staphylococcus aureus manipulates inflammasome activities critical to host defense. The funded research identifies mechanisms by which diverse S. aureus strains, including toxigenic and non-toxigenic variants, activate inflammasome regulatory proteins in immune cells....
The National Institute of Allergy and Infectious Diseases awarded Rutgers, The State University $421,889 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate cytosolic copper ion accumulation and proteome integrity in Staphylococcus aureus. The project addresses antimicrobial resistance in S. aureus and other ESKAPE pathogens by examining how copper ions toxify bacteria through protein misfolding and aggregation. The research characterizes copper ion toxicity mechanisms, determines the role of protein homeostasis machinery in preventing copper toxicity, and investigates why specific mutations in rpoB and rpoC increase bacterial tolerance to copper ions. Preliminary data demonstrate that copper(II) treatment increases protein misfolding and aggregation in S. aureus, and that chemical inhibition of protein maintenance machinery synergizes with copper(II) to kill bacteria. Understanding these mechanisms may illuminate strategies the mammalian immune system uses to prevent infection and inform development of novel antimicrobial therapies. Performance occurs at Rutgers' Piscataway, New Jersey campus. The award period runs through August 31, 2028. This is a Project Grant, the primary assistance type under NIAID's infectious disease research portfolio for supporting innovative research addressing emerging health challenges.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $421.9k | 9/2/26 |