Project Grant R21AI196675
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $709,891 Project Grant on August 1, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support a five-year research project extending through July 31, 2030. The award funds structural and mechanistic research on the polar tube invasion apparatus of microsporidian parasites, unicellular fungal pathogens that cause opportunistic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $147,486 Project Grant effective September 21, 2025, through April 30, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports investigator-initiated research aimed at identifying metabolic targets to reinvigorate exhausted CD8+ T cells, which become dysfunctional following prolonged antigen exposure and exhibit poor...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $426,938 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 23, 2025, with a completion date of May 31, 2027. The award supports the development of a simplified, cost-effective mouse model of chronic Mycobacterium abscessus lung disease using BALB/c mice that requires only weekly cyclophosphamide administration. This...
- Federal Grant Award Summary The Johns Hopkins University received a $765,422 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 17, 2026, with completion targeted for March 31, 2031. This research initiative focuses on systematically studying the mechanisms of antigen diversification in Trypanosoma brucei, a protozoan parasite that causes African trypanosomiasis. The...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $700,997 Project Grant effective April 1, 2026, through March 31, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This research initiative will investigate immune homeostasis dysfunction induced by Borrelia burgdorferi (Bb) infection, the causative agent of Lyme disease. The project addresses a significant gap in understanding how...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $427,438 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. The grant funds research to identify and eliminate antigen-specific expanded clones of latently infected CD4+ T cells, which are believed to contribute significantly to the HIV reservoir. The research team will...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $3.15 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective September 19, 2025, through August 31, 2029. The research investigates macrophage senescence as a driver of granuloma failure and progression to necrosis in tuberculosis (TB) and TB/HIV co-infection. The study aims to understand fundamental mechanisms of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $427,313 on February 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigator-initiated biomedical research on tertiary lymphoid structures in eosinophilic chronic rhinosinusitis with nasal polyps (ECRSWNP). The research will be performed in Baltimore, Maryland, with a completion date of January 31,...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $155,227 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 9, 2025, with completion scheduled for May 31, 2027. The grant supports proof-of-concept research on an unconventional treatment regimen for Mycobacterium abscessus (MAB) chronic lung disease, a rapidly progressive non-tuberculous...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $426,625 Project Grant (CFDA 93.855, Allergy and Infectious Diseases Research) beginning August 7, 2025, and concluding July 31, 2027, to conduct quantitative assessment research on the Dual Path Platform (DPP) Syphilis TNT (Treponemal and Non-Treponemal) assay. The research addresses a significant public health need by evaluating the feasibility of using this...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $423,355 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026 through March 31, 2028. This award funds fundamental research into cell polarity mechanisms in Rickettsia parkeri, an obligate intracellular bacterial pathogen that causes spotted fever group diseases in humans. The research will employ proximity labeling techniques to comprehensively identify polar proteins in R. parkeri and functionally characterize the role of the polar organizing protein PopZ in bacterial growth and host cell interactions, with anticipated completion of foundational knowledge on rickettsial cell biology mechanisms applicable to therapeutic development. The deliverables under this award include scientific research outputs and experimental findings examining cell polarity factors in an important human pathogen. Specifically, the project will produce results from two primary research aims: identification and validation of the polar protein repertoire through proteomics analysis, and functional characterization of PopZ using transposon mutant approaches. These research products will contribute to the NIAID program's objective of establishing and expanding biomedical research addressing infectious diseases, with potential applications to understanding and controlling rickettsial disease mechanisms.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.4k | 4/1/26 |