This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $910,905.00 to the Scripps Research Institute to advance HIV vaccine development using a lipid nanodisc platform. The key objectives are to: Solve the structures of engineered transmembrane HIV envelope (Env) proteins incorporated into lipid nanodiscs in complex with broadly neutralizing antibodies targeting the...
This $459,999 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director (CFDA 93.310 - Trans-NIH Research Support) supports research by the Scripps Research Institute in La Jolla, CA to develop predictive modeling of viral RNA cellular behavior. The key objectives are to: 1) Develop high-throughput technologies that integrate 3D structural ensembles of biomolecules with quantitative measurements of in vitro and cellular functions to build predictive models...
The Scripps Research Institute was awarded a $779,915 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The 5-year grant, effective May 5, 2025, will support research to investigate the chromatin remodeling functions of polyphosphate condensates in the opportunistic pathogen Pseudomonas aeruginosa. The project aims to define the relationship between polyphosphate, a stress-responsive...
This Project Grant award of $438,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop new tools to facilitate drug discovery for pathogen proteasomes. The funded project at the University of California, San Diego aims to address two key bottlenecks in advancing research on parasite proteasomes - the difficulty in isolating and purifying parasite 20S proteasome enzymes,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $899,935 to the Scripps Research Institute to identify novel B cell epitopes on the SARS-CoV-2 spike protein and other human coronaviruses. The goal is to uncover broadly neutralizing antibody epitopes that can inform the design of next-generation COVID-19 vaccines and therapeutics, enhancing pandemic preparedness. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support the development and high-content screening of a library of over 50,000 bifunctional interferon chimera proteins. The goal is to identify and validate improved cell stimulatory functions of these protein chimeras, which have potential applications for treating conditions like multiple sclerosis. The $807,664 award...
The National Institutes of Health National Institute of Allergy and Infectious Diseases awarded $852,121.24 to The Scripps Research Institute-Florida under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of July 22, 2021 through October 31, 2021. The project aims to identify host factors that regulate HIV latency and reactivation in order to develop strategies for durable HIV silencing. The grantee will define the roles of three identified host factors, P32,...
This federal Project Grant award, with ID R21AI187731, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $245,895 award, granted on November 14, 2024, supports research at the Icahn School of Medicine at Mount Sinai to systematically assess the impact of ubiquitination on Flavivirus infection using CRISPR-Cas9 base editing approaches. The goal is to discover novel pathways that promote...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop an innovative proteoliposome-based delivery system for therapeutic and bioactive cargo. The $213,284 award will fund research to repurpose viral fusion machinery, including proteins from influenza, Nipah virus, and SARS-CoV-2, to improve cellular uptake and targeted delivery of user-defined cargo. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute. The purpose of this 2-year grant, with a start date of January 23, 2025, is to evaluate recently discovered neuraminidase broadly neutralizing antibodies (NA BnAbs) for their potential use in a universal influenza vaccine. The research will assess factors such as precursor frequency,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $506,000.00 to the Scripps Research Institute to develop high-throughput technologies for generating and screening small interfering RNA (siRNA)-peptide conjugates. The goal is to improve the delivery efficiency and overcome key bottlenecks of cellular uptake, endosomal escape, and siRNA activation for antiviral therapeutics. The project aims to adapt mRNA display technology to synthesize diverse siRNA-peptide libraries and evaluate their functionality using biochemistry and small RNA sequencing. This work supports NIAID's mission to combat infectious diseases through innovative therapeutics and the development of broadly applicable antiviral treatments. The project period runs from July 9, 2025 to June 30, 2027.