Project Grant R01AI190286

Award Date 6/10/25
Completion Date 5/31/30
Dollars Obligated $900K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $247,750 to support structural investigations of the SARS-CoV-2 spike protein. The research aims to characterize how glycosylation (the addition of sugar molecules) of the spike protein affects its structure and function, which is critical for virus entry and immune system interactions. This research will...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,000 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Scripps Research Institute to support research on developing a broad-spectrum influenza vaccine. The project aims to evaluate recently discovered neuraminidase (NA) broadly neutralizing antibodies (bNAbs) and use directed evolution techniques to design NA immunogens that can engage diverse bNAb precursors. This "germline...
This $380,320 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the dynamics of human CD8 T cell responses to SARS-CoV-2 and investigate how CD8 T cell homeostasis may be altered in Long COVID. The research aims to define the differentiation lineages of SARS-CoV-2-specific CD8 T cells, understand how epigenetic features influence their functional...
This $705,557 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will fund research at Emory University to investigate the role of monocytes and T cells in promoting viral control and clearance of SARS-CoV-2 in the upper and lower respiratory tract. Specifically, the research aims to determine the contribution of monocytes in supporting protective T cell responses,...
This federal Project Grant award of $867,563 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop a pioneering class of nanobodies designed to provide comprehensive protection against all betacoronaviruses, including SARS-CoV-1, MERS-CoV, and SARS-CoV-2. The research aims to strategically expand nanobody repertoires, identify synergistic nanobody pairs, and optimize critical...
This $318,085 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to better understand the role of antibodies, antigens, and cellular immunity in controlling viral infections through Fc-dependent mechanisms like antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research...
This Federal Project Grant award of $755,225.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a novel vaccine to prevent emerging pandemic coronaviruses. The key objectives are to: 1) Develop a papillomavirus-like particle (PV-VLP) based, T cell-inducing mucosal coronavirus vaccine targeting conserved coronavirus antigens (S2, M, and N) using gene rearrangement and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $240,516 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Kentucky Research Foundation. The grant, awarded on July 11, 2024, will fund research to understand the mechanism of SARS-CoV-2 viral entry by using single-molecule approaches. The key objectives are to measure the binding dynamics of the SARS-CoV-2 spike protein and ACE2 receptor, determine the kinetics...
This $459,999 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director (CFDA 93.310 - Trans-NIH Research Support) supports research by the Scripps Research Institute in La Jolla, CA to develop predictive modeling of viral RNA cellular behavior. The key objectives are to: 1) Develop high-throughput technologies that integrate 3D structural ensembles of biomolecules with quantitative measurements of in vitro and cellular functions to build predictive models...
This $15,981,588 project grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases aims to develop pan-coronavirus vaccines. Led by Washington University, the collaborative program includes eleven laboratories seeking to design optimized B and T cell antigens conferring broad immunity against sarbecoviruses and merbecoviruses. The three-year award beginning September 2022 supports three integrated research projects and two centralized cores. Project 1...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $899,935 to the Scripps Research Institute to identify novel B cell epitopes on the SARS-CoV-2 spike protein and other human coronaviruses. The goal is to uncover conserved and cryptic epitopes that can elicit broadly neutralizing antibodies, with the aim of informing the design of next-generation coronavirus vaccines and therapeutics to enhance pandemic preparedness. Key activities include comprehensive characterization and high-resolution structural determination of over ten B cell epitopes on the SARS-CoV-2 spike, as well as the identification of unexplored, cryptic, and pan-coronavirus epitopes using diverse donor samples and state-of-the-art multi-bait B cell isolation strategies. This 5-year project, running from June 2025 to May 2030, represents a critical effort to expand the understanding of coronavirus immunology and develop innovative solutions to address current and future pandemic threats.

Generated 7/1/25, 2:33 AM