Evaluation of peg-bpei as a potential mitigator against gastrointestinal acute radiation syndrome
Active Project Grant Awarded Last action
- Award ID
- R21AI194027
- Recipient
-
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. UEI UYLKBRENAPG5
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $149,008
Award facts
- Assistance listing
- 93.310 Trans-NIH Research Support
- Completion date 41% complete
- Originally
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- Maryland, USA
Award details come from USAspending.gov.
Description
- Abstract
- Gastrointestinal (GI) toxicity remains a significant contributor to mortality following exposure to ionizing radiation (IR), leading to a severe condition known as GI acute radiation syndrome (GI-ARS). The lack of effective treatments for GI-ARS has underscored the urgent need for development of medical countermeasures (mcms) to mitigate its devastating effects. To address this unmet medical need, we have developed a murine model of partial body irradiation (PBI) that simulates a scenario GI injury is created while a small portion of hematopoietic system is spared. This model allows US to study the specific effects of radiation on the GI tract while minimizing systemic toxicity. Using a clinical linear accelerator, we have determined the LD50/30, the lethal dose of radiation that kills 50% of the animals within 30 days, for both male and female mice in this model. This LD50/30 serves as a critical benchmark for evaluating the efficacy of potential mcms. Given the ability of peg-bpei to combat bacterial infections by killing both gram-positive and gram-negative bacteria, disabling antibiotic resistance mechanisms, neutralizing endotoxins, and dispersing biofilms, we hypothesize that IT can mitigate leaky GUT post-radiation. By reducing the burden of infection, peg-bpei may enhance GI tissue repair, reduce inflammation, and ultimately improve survival rates in mice exposed to ionizing radiation.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $149,008 |
Quick answers
Who received award R21AI194027?
R21AI194027 was awarded to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on August 1, 2025.
How much is award R21AI194027 worth?
$149,008 has been obligated on R21AI194027.
Which agency awarded R21AI194027?
National Institute of Allergy and Infectious Diseases (National Institutes of Health) awarded R21AI194027, with funding from Office of the Director (National Institutes of Health).
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award