The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $812,603 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Houston System. The grant aims to develop selective calcium-dependent protein kinase 1 (CDPK1) inhibitors that can efficiently access the gastrointestinal system to treat cryptosporidiosis, a significant public health threat with limited treatment options. The research will focus on structure-activity...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $206,116 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Oregon Health & Science University (OHSU) to develop novel 4-aminoquinoline compounds as therapeutics against multi-drug resistant Plasmodium falciparum, the deadliest species of malaria parasite. The project aims to further develop a compound, MH02-060, that has shown enhanced metabolic stability and in vivo efficacy...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $223,176 to The Trustees of the University of Pennsylvania to investigate the molecular architecture and ultrastructural features of the Cryptosporidium host-parasite interface. The research aims to uncover the three-dimensional structure, composition, and function of key interface components like secreted...
This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $657,673 to the Regents of the University of Minnesota to conduct research on non-deletional CD8+ T cell tolerance. The research aims to define the gene regulation that inhibits self-reactive CD8+ T cells and classify different types of self-reactive CD8+ T cell clones, in order to understand which tolerance...
This Project Grant award of $438,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop new tools to facilitate drug discovery for pathogen proteasomes. The funded project at the University of California, San Diego aims to address two key bottlenecks in advancing research on parasite proteasomes - the difficulty in isolating and purifying parasite 20S proteasome enzymes,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 Allergy and Infectious Diseases Research, provides $423,500.00 to the Regents of the University of Minnesota to conduct research on phenylalanine (Phe) biosynthesis as a potential drug target for treating tuberculosis (TB). The research aims to determine the extent to which Mycobacterium tuberculosis (MTB) requires Phe synthesis during infection and how inhibiting Phe...
This Project Grant award of $375,000.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project to investigate the role of messenger ribonucleoprotein (mRNP) granules in regulating RNA metabolism and translation in the malaria parasite Plasmodium falciparum. The project aims to identify molecular markers for distinct mRNP types, determine their protein and mRNA compositions, and characterize their...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,999,774 to the Regents of the University of Minnesota to conduct research focused on understanding how maternal microbial exposure fundamentally shapes the CD8 T cell population at the maternal-fetal interface. The key objectives are to investigate the regulation of CD8 T cell tolerance and host immune defense...