This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $375,000.00 in funding to the University of South Florida to conduct research on the functions of messenger ribonucleoproteins (mRNPs) in regulating RNA metabolism in the malaria parasite Plasmodium falciparum. The key objectives of this 5-year research project are to: 1) identify molecular markers for distinct mRNP types, determine their protein and mRNA compositions, and characterize their dynamics across different parasite life stages and under stress conditions; and 2) investigate the roles of key RNA-binding proteins within the mRNP granules in regulating mRNA stability, decay, and translatability. This research aims to provide a comprehensive understanding of the diverse functions of mRNPs in controlling critical aspects of P. falciparum biology, which could lay the groundwork for discovering new antimalarial drug targets.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $375.0k | 6/10/25 |