Project Grant R01AI187187

Award Date 6/10/25
Completion Date 5/31/30
Dollars Obligated $375K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Tampa, FL 33612, USA
Similar Awards
This $215,751 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify and characterize RNA-binding proteins (RBPs) and RNA-dependent proteins (RDPs) in the malaria parasite Plasmodium falciparum. The research team at the University of California, Riverside will use an unbiased proteome-wide approach, called R-DEEP, to detect RBPs and RDPs during the parasite's sexual...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $700,288 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of South Florida (USF) to conduct phenotype-based screens and functional genomics research to identify genetic factors associated with gametocyte development in Plasmodium falciparum, the major global cause of malaria. The project, running from November 2024 to October 2029, will use a random piggyBac mutagenesis approach to...
This Project Grant award of $791,864, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify the molecular factors that control chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The primary goal is to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, and...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This Project Grant award of $153,056.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research into understanding heme homeostasis mechanisms in the malaria parasite Plasmodium falciparum. The key objectives are to: 1) Identify parasite heme-binding proteins using a click-chemistry based approach and assess their essentiality through conditional knockdown experiments, and 2) Investigate...
The federal Project Grant award of $459,131, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports research to identify essential functions of the mitochondrion in malaria parasites. The goal is to uncover novel drug targets within the parasite mitochondrion that could lead to the development of new antimalarial treatments effective against both symptomatic and transmission stages of malaria...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,104,050 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis. The grant will fund research to investigate the molecular mechanisms by which the Plasmodium falciparum malaria parasite's secreted histidine-rich protein II (HRPII) impairs the function of human neutrophils, a critical component of the immune response. The goal is to elucidate...
This $1,480,500 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will fund research by The Trustees of Columbia University in the City of New York to identify and characterize the roles of non-coding RNAs in regulating drug-induced quiescence in Plasmodium falciparum, the parasite that causes malaria. The project aims to uncover novel epigenetic and epitranscriptomic mechanisms that enable...
This federal Project Grant award R01AI183599 in the amount of $1,553,810 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to evaluate a genomic surveillance approach for monitoring the emergence of artemisinin resistance in Plasmodium falciparum malaria parasites in Africa. The key objectives are to: 1) identify parasite genetic loci under selection over time...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $699,814 to Florida International University (FIU) to study the molecular mechanisms of Plasmodium-Anopheles midgut interactions and develop novel transmission-blocking vaccine approaches for malaria. The key objectives are to functionally characterize mosquito and parasite proteins involved in midgut invasion,...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $375,000.00 in funding to the University of South Florida to conduct research on the functions of messenger ribonucleoproteins (mRNPs) in regulating RNA metabolism in the malaria parasite Plasmodium falciparum.

The key objectives of this 5-year research project are to: 1) identify molecular markers for distinct mRNP types, determine their protein and mRNA compositions, and characterize their dynamics across different parasite life stages and under stress conditions; and 2) investigate the roles of key RNA-binding proteins within the mRNP granules in regulating mRNA stability, decay, and translatability. This research aims to provide a comprehensive understanding of the diverse functions of mRNPs in controlling critical aspects of P. falciparum biology, which could lay the groundwork for discovering new antimalarial drug targets.

Generated 7/1/25, 3:41 AM