Project Grant R21AI193904
Award Date 8/6/26
Completion Date 7/31/28
Dollars Obligated $197K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
State College, PA 16802, USA
Similar Awards
- The National Institute of Allergy and Infectious Diseases awarded The Pennsylvania State University $247,000 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study mechanisms of translational repression release in Plasmodium parasites during transmission from mammals to mosquito vectors. The research applies reverse genetic, transcriptomic, proteomic, and microscopy-based approaches to determine how malaria parasites control gene expression before and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Pennsylvania State University $196,625 on May 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct single-cell transcriptomics research on sexual dimorphism during Plasmodium falciparum gametocytogenesis. The research applies single-cell RNA sequencing to uncover the molecular mechanisms governing sexual development and differentiation in the malaria parasite. The study...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded The Pennsylvania State University $235,950 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on engineering artificial endosymbiosis in mosquitoes using synthetic biology. The project addresses fundamental gaps in understanding obligate endosymbionts—microorganisms living within eukaryotic host cells—and their potential...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded Purdue University $239,023 on August 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop covalent phosphatidylinositol 4-kinase (PI4K) inhibitors targeting malaria parasites. The project executes hit-to-lead optimization of high-priority molecular scaffolds against Plasmodium species that inhibit...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $788,453 under Project Grant R01AI198560 on September 2, 2026, to identify essential Plasmodium falciparum determinants of erythrocyte invasion using genome-scale functional genomic approaches. The research will employ a novel transposon-based strategy to map critical genes and molecular pathways underlying red blood cell invasion across multiple P. falciparum strains with distinct phenotypes in...
- The National Institute of Allergy and Infectious Diseases awarded Pennsylvania State University's Penn State Milton S. Hershey Medical Center $430,650 on June 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to probe the mechanism of HIV-1 GAG localization to transcription sites. The research addresses a gap in understanding how HIV-1 GAG protein locates and binds to genomic RNA during viral particle assembly. Conventional models posit that GAG-viral RNA...
- The National Institute of Allergy and Infectious Diseases awarded the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. $223,728 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Plasmodium falciparum gametocyte differentiation and adhesion mechanisms as part of Project Grant R21AI199783. The funded research addresses malaria transmission by examining the sexual stage parasites (gametocytes) responsible for...
- The National Institute of Allergy and Infectious Diseases awarded $222,457 to Pennsylvania State University on June 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize structural polymorphism in native murine polyomavirus isolated from mouse cells. The research applies single-particle cryo-electron microscopy, cryo-electron tomography, and charge detection mass spectrometry to define the molecular architecture and polymorphic assembly pathways of...
- The National Institute of Allergy and Infectious Diseases awarded The Pennsylvania State University $113,853 on December 12, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate polymicrobial interactions in bile acid metabolism by the gut microbiome. The research decodes cross-species metabolic pathways through which gut bacteria convert host-derived primary bile acids into secondary bile acids, including 7a-dehydroxylated deoxycholic acid and...
- The National Institute of Allergy and Infectious Diseases awarded Texas State University $188,124 on August 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on the molecular basis for Plasmodium rhoptry development. The research investigates how the aspartic protease plasmepsin IX and the glycosylphosphatidylinositol-anchored rhoptry-associated membrane antigen coordinate during rhoptry maturation in the malaria parasite. Rhoptries are...