Project Grant R21AI193884
- This $153,169 federal Project Grant award from the National Institutes of Health (CFDA 93.310 Trans-NIH Research Support program) to The Ohio State University aims to develop a rapid, non-invasive method for assessing radiation exposure using Raman spectroscopy and artificial intelligence. The project will collect and analyze hair samples from mice exposed to controlled radiation doses to develop models for detecting exposure greater than 2 Grays and differentiating higher doses above 5 Grays....
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to develop a non-invasive, painless biodosimeter using Fourier transform infrared attenuated total reflection (FTIR-ATR) imaging and statistical machine learning. The $197,930 award will fund research to expand upon preliminary data showing FTIR-ATR imaging can distinguish irradiated from control mice at doses as low as...
- The National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Georgetown University on August 11, 2025. The project, titled "Development of a Multiomic Biodosimetry Panel for Use During Sepsis and Antibiotic Treatment", aims to develop a novel panel of metabolomic and gene expression biomarkers to rapidly screen and provide accurate dose reconstruction for individuals exposed to ionizing radiation. This panel will...
- The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. The overall objective of this 2-year project, from August 1, 2025 to July 31, 2027, is to develop a panel of biomarkers that can discriminate between exposure of upper- and lower-body organs to radiation and predict health outcomes. The research aims to identify organ-specific...
- The National Institutes of Health (NIH) awarded a $350,000 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. to deliver a field-ready, physically-based biodosimetry device capable of accurately estimating radiation doses in the range of 0-10 Gy within 0.5 Gy and estimating the homogeneity of irradiation exposure using in vivo measurements of human nails. The project aims to enhance biodosimetry capabilities by improving...
- This Cooperative Agreement award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $376,017 to Wake Forest University Health Sciences (WFUHS) to develop a novel solid-state nanopore-based technology for rapid and sensitive assessment of radiation exposure. The project aims to create a panel of DNA-based biomarkers that can precisely measure radiation exposure levels from 0-10 Gy, as well as determine the radiation source modality....
- This $164,500 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports the development and validation of human normal tissue patient-derived organoids (NT-PDOs) for pre-screening new candidate gastrointestinal (GI) radiation countermeasure drugs. The goal is to create an extracorporeal model based on healthy human GI tissue that can accurately assess the efficacy and safety of radiation mitigators, addressing limitations of...
- This Project Grant award, totaling $156,000.00, was provided by the Office of the Director of the U.S. Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The project aims to develop a novel, dual-specimen biomarker strategy to improve early detection of gastrointestinal acute radiation syndrome (GI-ARS) using angiotensin-converting enzyme 2 (ACE2) as an early tissue-specific biomarker. The study, conducted by...
- This Cooperative Agreement award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $576,303 to Duke University to develop "ORP100S", an engineered version of the human protein thioredoxin, as a therapeutic agent for mitigating radiation-induced injury. The 5-year project aims to further define the efficacy of ORP100S in protecting hematopoietic stem cells and other organ systems from lethal radiation doses, even when administered...
- This Cooperative Agreement award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $616,202 to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Inc., to identify and develop non-invasive biomarkers of radiation exposure in human skin. The project aims to utilize a model of irradiating human skin grafts carried by immunodeficient mice to identify and validate keratinocyte biomarkers that can discriminate between...
This $157,400 federal Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) is funding the development of an artificial intelligence (AI)-powered cytogenetic biodosimetry platform to rapidly detect chromosomal aberrations for radiation triage following radiological or nuclear incidents. The award to the Georgia TECH Research Corp, doing business as the Office of Sponsored Programs, will leverage the recently released YOLOV9 neural network to detect a range of chromosomal abnormalities across radiation dose levels. The project will also integrate classification algorithms to categorize individuals into low, moderate, or high exposure levels, aiming to enable more personalized and accurate interventions compared to traditional 2 Gy triage thresholds. This research effort, with a performance period from August 1, 2025 to July 31, 2027, seeks to provide a faster, more automated, and higher-throughput radiation biodosimetry capability to support effective triage and response during large-scale radiological or nuclear emergencies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $157.4k | 7/31/25 |