Project Grant R21AI194022
- The Cooperative Agreement award, issued by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), provides $595,009 to The Trustees of Columbia University in the City of New York to develop MIIST305 as a mitigator for gastrointestinal acute radiation syndrome and identify biomarkers of radiation injury and drug efficacy. The project aims to address the critical need for effective medical countermeasures against radiation-induced gastrointestinal...
- The Project Grant titled "Engineered Microbes to Mitigate Intestinal Radiation Damage" was awarded by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The $160,125 award to Baylor College of Medicine aims to explore the use of the microbiome to deliver growth factors that promote survival and proliferation of radioresistant intestinal stem cells. The objective is to assess a genetically...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $149,008 to evaluate the use of PEG-BPEI as a potential mitigator against gastrointestinal acute radiation syndrome (GI-ARS). The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. will develop a murine model of partial body irradiation to study the effects of radiation on the GI tract while minimizing systemic...
- The National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Georgetown University on August 11, 2025. The project, titled "Development of a Multiomic Biodosimetry Panel for Use During Sepsis and Antibiotic Treatment", aims to develop a novel panel of metabolomic and gene expression biomarkers to rapidly screen and provide accurate dose reconstruction for individuals exposed to ionizing radiation. This panel will...
- This Project Grant award, totaling $156,000.00, was provided by the Office of the Director of the U.S. Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The project aims to develop a novel, dual-specimen biomarker strategy to improve early detection of gastrointestinal acute radiation syndrome (GI-ARS) using angiotensin-converting enzyme 2 (ACE2) as an early tissue-specific biomarker. The study, conducted by...
- The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. The overall objective of this 2-year project, from August 1, 2025 to July 31, 2027, is to develop a panel of biomarkers that can discriminate between exposure of upper- and lower-body organs to radiation and predict health outcomes. The research aims to identify organ-specific...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $155,000 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the mitochondrial serine/threonine phosphatase PGAM5 as a potential target for mitigating gastrointestinal acute radiation syndrome (GI-ARS). The research aims to examine the role of PGAM5 in radiation-induced oxidative stress and modulation of Wnt/β-catenin...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $164,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Albany Medical College. The grant supports research into "Specialized Pro-Resolving Lipid Mediators for Systemic Radiation Countermeasures". The research aims to develop new therapies to address radiation-induced damage, including hematopoietic effects and chronic inflammation, which can result from...
- This $167,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to develop the pentapeptide MSP68 as a novel and effective medical countermeasure to treat the gastrointestinal acute radiation syndrome (GI-ARS). The grant recipient, The Feinstein Institutes For Medical Research, will conduct research to demonstrate that MSP68 can mitigate GI-ARS by promoting the recovery of gut stem cells and reducing intestinal damage...
- This Project Grant award of $157,400 from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) is focused on developing an effective medical countermeasure against gastrointestinal acute radiation syndrome (GI-ARS). The primary objective is to establish the efficacy of Maroon Biotech's MP8800 copolymer in increasing 10-day and 30-day survival rates, as well as preserving gut barrier function, in a well-established rat model of GI-ARS. The research is...
This $164,500 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports the development and validation of human normal tissue patient-derived organoids (NT-PDOs) for pre-screening new candidate gastrointestinal (GI) radiation countermeasure drugs. The goal is to create an extracorporeal model based on healthy human GI tissue that can accurately assess the efficacy and safety of radiation mitigators, addressing limitations of current animal-based testing approaches. The 2-year project, awarded to The Trustees of Columbia University in the City of New York, will leverage the university's expertise in biomedical research to establish NT-PDO models that replicate human GI tissue responses, enabling high-throughput pre-screening of candidate GI radiation countermeasure drugs. This work seeks to advance the development of effective medical countermeasures for acute radiation syndrome, which is critical for addressing potential radiological or nuclear events.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $164.5k | 8/19/25 |