Project Grant R21AI193785
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) totaling $157,000.00 is supporting research to develop a new class of radiation mitigating agents as medical countermeasures for hematopoietic acute radiation syndrome (H-ARS). The principal investigators from the collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences will examine the mitigating effects of the small molecule...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $155,857 Project Grant under the Trans-NIH Research Support (CFDA 93.310) program to Signablok, Inc. in Massachusetts. The funding supports the development of a novel medical countermeasure to mitigate potentially lethal acute radiation syndrome (ARS). The project aims to create a well-tolerable and effective first-in-class therapeutic that can be administered at least 24 hours post-radiation exposure...
- This Cooperative Agreement award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $616,202 to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Inc., to identify and develop non-invasive biomarkers of radiation exposure in human skin. The project aims to utilize a model of irradiating human skin grafts carried by immunodeficient mice to identify and validate keratinocyte biomarkers that can discriminate between...
- This Project Grant award of $153,000.00, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), focuses on investigating potential radiomitigating strategies for gastrointestinal acute radiation syndrome (GI-ARS). The research project has two novel approaches: 1) Evaluating the mitigating effects of dietary methionine restriction on GI-ARS following radiation exposure, and 2) Exploring a second approach outlined in Aim 2 (details not...
- This Cooperative Agreement award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $576,303 to Duke University to develop "ORP100S", an engineered version of the human protein thioredoxin, as a therapeutic agent for mitigating radiation-induced injury. The 5-year project aims to further define the efficacy of ORP100S in protecting hematopoietic stem cells and other organ systems from lethal radiation doses, even when administered...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to develop a non-invasive, painless biodosimeter using Fourier transform infrared attenuated total reflection (FTIR-ATR) imaging and statistical machine learning. The $197,930 award will fund research to expand upon preliminary data showing FTIR-ATR imaging can distinguish irradiated from control mice at doses as low as...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $164,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Albany Medical College. The grant supports research into "Specialized Pro-Resolving Lipid Mediators for Systemic Radiation Countermeasures". The research aims to develop new therapies to address radiation-induced damage, including hematopoietic effects and chronic inflammation, which can result from...
- The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. The overall objective of this 2-year project, from August 1, 2025 to July 31, 2027, is to develop a panel of biomarkers that can discriminate between exposure of upper- and lower-body organs to radiation and predict health outcomes. The research aims to identify organ-specific...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $155,000 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the mitochondrial serine/threonine phosphatase PGAM5 as a potential target for mitigating gastrointestinal acute radiation syndrome (GI-ARS). The research aims to examine the role of PGAM5 in radiation-induced oxidative stress and modulation of Wnt/β-catenin...
- The National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Georgetown University on August 11, 2025. The project, titled "Development of a Multiomic Biodosimetry Panel for Use During Sepsis and Antibiotic Treatment", aims to develop a novel panel of metabolomic and gene expression biomarkers to rapidly screen and provide accurate dose reconstruction for individuals exposed to ionizing radiation. This panel will...
This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support program) is focused on investigating the use of gaseous molecules, specifically xenon, as medical countermeasures to mitigate and treat radiation-induced skin injury. The $155,083 award will fund in vitro studies to assess the ability of xenon gas to regulate oxidative stress, reduce inflammation, and limit cellular senescence in human skin cells exposed to ionizing radiation. Computational modeling will also be conducted to identify novel gas-protein targets. Additionally, the study will test the use of a gas marble delivery system to administer the known radiomitigating gas hydrogen (H2) in a small animal model to ameliorate cutaneous radiation injury. The award was made to the University of Arizona and has a performance period from September 2025 to August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.1k | 9/23/25 |