This federal Project Grant award, valued at $472,210.00 and effective June 23, 2025 through May 31, 2027, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research by the University of Massachusetts Medical School to investigate the spatiotemporal relationship between CD4+ T resident memory cells and neutrophil recruitment in the lungs during pneumonia in experienced...
This Project Grant from the National Institutes of Health National Institute on Aging provided $227,436.88 to study the role of neutrophils in the age-driven decline of anti-pneumococcal vaccine responses. The Research Foundation for the State University of New York served as the awardee and Sponsored Projects Services as the vendor to carry out the research from June 15, 2021 to September 29, 2021. The objectives of the research were to test the role of neutrophils as effectors in the decline...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the molecular mechanisms of the high temperature requirement A (HtrA) serine protease in the pathogenic bacterium Streptococcus pneumoniae. The $189,150 award to the University of Colorado-Denver will fund a 2-year study to investigate the structural rearrangements and dynamics of the S....
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $479,249 to Washington University to conduct research on the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis. The research aims to understand how neutrophil A20 signaling contributes to organ damage in sepsis, utilizing biochemical, cell biological, and intravital imaging...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $445,338 to the University of Washington to conduct research on the mechanisms of age-related lung inflammation in pulmonary melioidosis. The project aims to determine how monocyte function impacts age-dependent neutrophilic inflammation in the lung during pulmonary melioidosis infection, and to define...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $160,095 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to St. Jude Children's Research Hospital Inc. in Memphis, TN. The grant supports research to determine how the presence of mucin, a key component of mucus, inhibits autolysis (self-destruction) of the pathogenic bacterium Streptococcus pneumoniae. The research aims to understand how mucin promotes prolonged survival of...
This Project Grant award of $759,983 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the University of North Carolina at Chapel Hill supports research examining the diverse responses of neutrophils during Streptococcus pneumoniae pneumonia and acute lung injury. The research aims to determine changes in neutrophil transcriptomes and the lung microenvironment during the development and resolution of S. pneumoniae-induced inflammation and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, provides $430,760 to the University of Pittsburgh to conduct research on improving host defense against the deadly Gram-negative bacterium, Pseudomonas aeruginosa. The key objectives are to: 1) Determine the role of the CXCR4 chemokine receptor and galectin-3 protein in the protective function of lung...
This Project Grant award of $226,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the mechanisms underlying robust innate immunity against Pneumocystis pneumonia (PCP) in the absence of CD4+ T cell function. The primary goals are to: 1) Define the early transcriptional profiles of lung epithelial cells from resistant and susceptible mouse strains upon interaction with...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $216,068 to the University of Alabama at Birmingham (UAB) to study the role of the PRP protease in the ribosome function of the pathogen Streptococcus pneumoniae. The key objectives are to define how PRP and cleavage of the L27 ribosomal protein impact ribosome assembly and activity, as well as examine the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $450,630 to Tufts University School of Medicine to conduct research on the interactions between the bacterial pathogen Streptococcus pneumoniae, pulmonary epithelial cells, and neutrophils that contribute to age-associated susceptibility to pneumococcal disease. The objectives are to utilize advanced microscopy techniques to spatiotemporally analyze the expression of the pneumolysin virulence factor and its impact on epithelial barrier disruption and neutrophil recruitment and function, particularly in the context of aging. This 2-year project aims to establish a new framework for understanding how heterogeneity in S. pneumoniae-host epithelial interactions affects the local neutrophil response and how aging modulates these dynamics.