This Project Grant award of $750,815, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research), supports research aimed at developing novel anti-infective strategies to treat pulmonary mucormycosis, a deadly invasive fungal infection. The key objectives are to: 1) examine the role of the host cell hypoxia-response pathway, specifically the protein ANGPTL4, in the pathogenesis of mucormycosis and explore its therapeutic...
This $134,800 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by Dr. Shakti Singh at the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The project aims to: Study the role of Hyr1/Iff-like (CAU-HIL) proteins in the virulence of the multidrug-resistant pathogen Candida auris, which causes life-threatening bloodstream infections....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $558,747 to Texas Tech University Health Sciences Center (TTUHSC) to conduct research on a novel link between calcineurin, amino acid permease, and protein kinase A in the virulence of the fungus Mucor, which causes the life-threatening condition mucormycosis. The 5-year project aims to identify key transcription...
This $300,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to discover and develop new, more potent antifungal therapies for treating invasive fungal infections such as cryptococcosis, candidiasis, and aspergillosis. The funding will support the continued screening of chemical libraries to identify lead compounds that selectively inhibit the fungal ceramide synthase 1...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $822,646 to support research into the mechanisms driving synergistic lethality in polymicrobial fungal-bacterial infections. The project aims to investigate how the fungal pathogen Candida albicans interacts with the bacterial pathogen Staphylococcus aureus to increase toxin production, dysregulate host immune and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research program provides $170,000.00 to Prokaryotics Incorporated, a pharmaceutical research company, to perform structure-based design of novel antifungal inhibitors targeting the glycosylphosphatidylinositol (GPI) ethanolamine phosphate transferase, MCD4. The research aims to develop mechanistically novel antifungal agents to address...
The University of Southern California (USC) received a $623,986 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The funding supports a research project to study the genetic and molecular mechanisms that enable fungi, specifically the opportunistic pathogen Saccharomyces cerevisiae, to persist and cause infections in mammalian hosts. Key objectives include: Identifying causal...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $642,775 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Davis. The funding will support research to accelerate the discovery of novel antifungal peptides using one-bead one-compound (OBOC) combinatorial technology. The project aims to develop a high-throughput screening platform to identify membrane-active antifungal peptides that can effectively...
This Project Grant award of $838,320.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the grant is to conduct research to define the genetic network in the fungus Aspergillus fumigatus that mediates its ability to cause invasive aspergillosis infections, particularly in the context of patients receiving Bruton's tyrosine kinase (BTK) inhibitor therapies for cancer. The...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $232,073 Project Grant (R21AI186688) to The Research Foundation For The State University Of New York (Stony Brook University) to explore the host-pathogen dynamics between the fungal pathogen Cryptococcus neoformans (CN) and HIV in microglia, the predominant immune cells in the brain. The overarching goal is to investigate how the accumulation...