Project Grant R21AI193486
- Federal Project Grant Award Summary The University of Virginia received a $806,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 11, 2026, through April 30, 2031. This award supports investigator-initiated biomedical research investigating the role of secreted bacterial effectors in neonatal intestinal dysbiosis and systemic spread of Group B Streptococcus (GBS)....
- Federal Grant Award Summary The University of Virginia received a $795,990 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 23, 2026, with a completion date of March 31, 2031. The research project, "Targeting Resistance at Its Source: Identifying Superspreaders of Antimicrobial Resistance Genes in Hospital Ecosystems," delivers scientific investigation and...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia $117,530 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on December 24, 2025, for a project period extending through June 30, 2028. This project grant supports research investigating the molecular mechanisms by which C4B-binding protein (C4BP), a human complement inhibitor, protects Neisseria gonorrhoeae from neutrophil-mediated...
- Federal Project Grant Award Summary The University of Virginia received a $717,952 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 9, 2026, with a completion date of January 31, 2031. This research initiative investigates the mechanisms by which Chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections, acquires and maintains lipids within...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia a $1,201,716 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 6, 2025, for research titled "Chemical Grammar of Accumulation in Drug Resistant Acinetobacter baumannii with Subcellular Resolution." The project, with performance in Charlottesville, Virginia, and completion scheduled for July 31, 2030, will develop...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia a Project Grant of $450,766 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, with completion targeted for July 31, 2027. This research initiative aims to characterize how Chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections, remodels inter-organelle communication within host cells to create a...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Tufts University School of Medicine a Project Grant of $453,750 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support investigator-initiated biomedical research. The award, effective February 2, 2026 through January 31, 2028, funds research examining how the bacterium Shigella flexneri evades the host immune response by suppressing pyroptosis—a critical...
- Federal Grant Award Summary The University of Virginia received a $256,725 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on May 21, 2026, with a completion date of April 30, 2028. This research project investigates catecholamine-mediated resistance to iron limitation in Neisseria gonorrhoeae (GC), the bacterium responsible for gonorrhea. The research addresses an urgent public...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of California, Berkeley a Project Grant of $751,663.00 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2031. The award funds research on the dissection of Shigella pathogenesis in vivo utilizing a newly developed oral infection mouse model. Shigella species cause bacillary dysentery, a severe...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant totaling $156,104 to the University of California, Berkeley under the Allergy and Infectious Diseases Research program (CFDA 93.855) on March 9, 2026, with a completion date of September 7, 2028. This award supports investigator-initiated biomedical research into the protective mechanisms of the gut microbiome against Shigella infection, a globally significant...
The University of Virginia received a $236,538 Project Grant awarded June 11, 2026, from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports a 23-month research initiative (through May 31, 2028) focused on characterizing biofilm formation mechanisms in Shigella flexneri, the causative agent of bacillary dysentery. The research addresses a significant global health burden, as S. flexneri infections result in approximately 250 million annual cases of dysentery with over 200,000 deaths worldwide. The funded research delivers scientific investigation into the dual functions of the bacterial protein IcsA in both intracellular pathogen dissemination and bile salt-dependent biofilm formation. Specifically, the project will characterize the structural determinants supporting IcsA-mediated biofilm formation (Aim 1) and evaluate the role of IcsA in extracellular and intracellular colonization using an infant rabbit model of shigellosis (Aim 2). The deliverables include novel mechanistic insights into bacillary dysentery pathogenesis that may inform future therapeutic and preventive strategies against this significant bacterial pathogen. Research will be conducted at the University of Virginia's Charlottesville, Virginia location.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $236.5k | 6/12/26 |