Project Grant R21AI193429

Award Date 7/7/25
Completion Date 6/30/27
Dollars Obligated $462K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Bronx, NY 10461, USA
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The research aims to use molecular dynamic simulation and functional in vitro/in vivo assays to define key molecular and TCR/epitope interaction features that promote the differentiation of stem cell-like memory CD8+ T cells. The goal is to develop an algorithm for identifying and designing T cell epitopes that favor the acquisition of stem cell-like properties by memory T cells. This work has the potential to improve the longevity and efficacy of vaccine-induced memory T cells and adoptively transferred T cells for chronic infections and cancers. The award period is from July 2025 through June 2027.

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