Project Grant R21AI188626

Award Date 1/14/25
Completion Date 12/31/26
Dollars Obligated $244K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Bronx, NY 10461, USA
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $520,809 in funding to Rosalind Franklin University of Medicine & Science over the period from September 5, 2024 to August 31, 2029. The overarching goal of this research project is to investigate the role of TAM receptors in modulating the humoral immune response against parasitic infections, such as malaria....
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This $423,500.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of Utah to investigate the role of invariant natural killer T (iNKT) cells in shaping the immune response to Plasmodium infection, which can lead to the severe neurological condition of cerebral malaria. The research aims to define how the T cell receptor (TCR) signaling properties of different iNKT cell...
This Federal Project Grant award of $131,154 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research by Yale University to quantify functional immune responses against Plasmodium falciparum, the parasite that causes malaria. The research objectives are to: 1) Assess mechanisms of protective blood-stage immune responses, including neutralization and opsonic phagocytosis, and 2) Understand how merozoite antigenic...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $244,440 to the Albert Einstein College of Medicine to investigate the mechanisms by which LY6C+ monocytes respond to and help clear microbial pathogen infections. The research aims to define the chemotactic cues, receptors, and molecular processes involved in how these monocytes home to infection sites and form stable...
This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
This $153,056 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Washington University will support research to investigate heme homeostasis mechanisms in the malaria parasite Plasmodium falciparum. The research aims to identify parasite heme-binding proteins and assess their essentiality for parasite viability, as well as investigate the role of the heme detoxification protein PfHDP in parasite...
This federal Project Grant award of $429,000.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine chromatin architecture and gene regulatory networks in Anopheles coluzzii mosquito hemocyte cells. The key objectives are to 1) map chromatin architecture during immune activation in mosquito hemocyte cells, and 2) identify gene regulatory networks for the immune...
This federal Project Grant award of $462,000.00 was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant will support research at Albert Einstein College of Medicine in Bronx, NY to design improved T cell epitopes for enhancing T cell vaccines and therapies. The research aims to use molecular dynamic simulation and functional in vitro/in vivo assays to define key molecular and TCR/epitope...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $738,445 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Drexel University to develop an mRNA-based multivalent malaria vaccine. The project aims to optimize mRNA vaccine-induced antibody-mediated and cell-mediated immune responses targeting pre-erythrocytic and blood-stage malaria parasites. Specifically, the grant will support the design, production, and evaluation of mRNA vaccine candidates...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $244,440.00 to Albert Einstein College of Medicine to conduct research on the role of cytolytic ZEB2+ memory CD4+ T cells in protection against liver stage malaria. The research aims to gain insights into the cellular immune determinants associated with natural clinical immunity to malaria, in order to inform the development of more effective second-generation malaria vaccines. The award period runs from January 14, 2025 to December 31, 2026. The research will utilize murine models of radiation-arrested sporozoites (RAS) immunization and sporozoite mosquito infection to explore the kinetics, differentiation requirements, functions, and protective capacity of circumsporozoite protein (CSP)-specific cytolytic CD4+ T cells during malaria infection.

Generated 8/5/25, 3:04 AM