Project Grant R21AI193187
- This $430,375.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on a novel inter-membrane lipid signaling mechanism in Gram-negative bacteria like E. coli and Pseudomonas aeruginosa. The research aims to elucidate how these bacteria can sense and respond to deficiencies in their outer membrane lipopolysaccharide (LPS) content, a critical component for...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $684,627 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to Georgia State University Research Foundation Inc. to investigate the interactions between the sexually transmitted pathogen Neisseria gonorrhoeae (the cause of gonorrhea) and host cell glycans. The research aims to understand how the pathogen's conserved outer membrane transport proteins bind to human glycans, potentially...
- The University of Georgia Research Foundation, Inc. was awarded a $650,020 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on August 1, 2025, supports research to determine the mechanisms by which memory regulatory T cells (mTregs) provide protection against recurring malaria infections caused by Plasmodium. The research aims to understand how mTregs transition to a T...
- The University of Georgia Research Foundation was awarded a $540,193 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The 12-month award, effective August 22, 2023, supports research to investigate the role of calcium-binding proteins and other secretory pathway components in the exocytosis of organelles critical for the invasion and egress of the malaria parasite Plasmodium falciparum...
- This federal Project Grant award, valued at $440,327.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of the grant is to investigate the mechanisms by which gram-negative bacteria, such as E. coli, traffic essential lipoproteins to the outer membrane, a critical barrier that protects these organisms. The research aims to uncover alternative lipoprotein trafficking pathways...
- This Project Grant award, valued at $416,276.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to investigate factors that modulate the Fc-mediated immune responses of antibodies. The research seeks to increase the potency of protection resulting from antibodies requiring Fc functions for influenza virus or antibodies against Streptococcus pneumoniae. The University...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, provides $361,297 to the University of Georgia Research Foundation to characterize the regulation of cell envelope biosynthesis in the bacterial pathogen Pseudomonas aeruginosa. The project aims to: (I) dissect the molecular basis of lipopolysaccharide (LPS) and peptidoglycan (PG) coordination and the physiological consequences of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin - Madison. The 5-year grant, effective from December 1, 2024 to November 30, 2029, will support research to elucidate the mechanisms by which prophages (viral DNA) in the gut symbiont Limosilactobacilus reuteri modulate the production of the antimicrobial compound reuterin. The research aims to...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $394,068 Project Grant to the University of Georgia Research Foundation, Inc. to investigate the molecular mechanisms of lipid transporters involved in bacterial cell wall biosynthesis. The project aims to elucidate the structure and function of two key lipid transporters, LtaA from the Major Facilitator Superfamily and TacF from the Multidrug...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $518,400 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The New York Structural Biology Center, Inc. (NYSBC) to determine the three-dimensional structure of a unique bipartite internal ribosome entry site (IRES) from the Giardia lamblia virus (GLV). This IRES violates the typical paradigm for viral IRES elements, as a significant portion resides within the coding region. The...
The University of Georgia Research Foundation, Inc. received a $415,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research CFDA program. The grant, awarded on Aug 21, 2025, aims to characterize a feedback signal balancing lipopolysaccharide and glycerophospholipid synthesis in Gram-negative bacteria. The research will develop analytical tools to quantify lipopolysaccharide transport intermediates and elucidate the kinetics of a regulatory system controlling lipopolysaccharide synthesis and proteolysis. The project will also investigate whether previously reported stimuli that alter lipopolysaccharide synthesis work through this regulatory system. The findings are expected to clarify the understanding of balancing lipopolysaccharide and glycerophospholipid synthesis in Gram-negative bacteria, which is critical for addressing increasing antibiotic resistance in these pathogens.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $415.3k | 8/21/25 |