This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $440,327 to Emory University to conduct research on lipoprotein trafficking to the bacterial outer membrane in gram-negative bacteria. The research aims to uncover additional factors responsible for lipoprotein trafficking beyond the known Lol pathway, and understand why multiple trafficking routes exist. It will also...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, provides $361,297 to the University of Georgia Research Foundation to characterize the regulation of cell envelope biosynthesis in the bacterial pathogen Pseudomonas aeruginosa. The project aims to: (I) dissect the molecular basis of lipopolysaccharide (LPS) and peptidoglycan (PG) coordination and the physiological consequences of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $693,422 to the University of Colorado-Denver from September 1, 2024 to August 31, 2029. The funding will support multidisciplinary research to pursue a fundamental mechanistic understanding of essential membrane transporters, which are critical for cellular function but generally understudied compared to other membrane proteins. The...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,616 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to New Mexico State University (NMSU). The 5-year grant, effective June 1, 2025 through March 31, 2030, will support research to elucidate the structure, function, and mechanism of bacterial zinc ATP-binding cassette (ABC) transporters. This work aims to develop a better understanding of these critical virulence factors in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000 in funding to the University of Texas Health Science Center at Houston (UTHealth) to conduct research on the biogenesis of the gram-negative bacterial cell envelope, with a focus on surface-exposed lipoproteins (SLPs). The research aims to elucidate the molecular mechanism by which the Beta-Barrel Assembly Machinery (BAM)...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences (CFDA 47.074) program provides $249,987 to Georgia Tech Research Corporation (Georgia Tech Research Corp) to study the structure and function of lipid antigen selection and presentation. The key objectives are to: Develop new machine learning-based predictive tools to model specificity and atomic structures of lipid/protein complexes. Apply integrated computational biology, biophysical assays, and structural...
This Project Grant award of $793,500 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research at the University of Tennessee at Chattanooga (UTC) to investigate changes in bacterial cell membrane dynamics due to polyunsaturated fatty acid (PUFA) modifications. The key objectives are to: 1) Interrogate the nature and degree of PUFA incorporation into membrane phospholipids of Vibrio cholerae, and 2)...
This Project Grant award of $769,644 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to functionally characterize the lysosome membrane and its protein quality control system. The primary objectives are to: 1) identify substrates of lysosomal E3 ligases in humans, 2) investigate the assembly of the ESCRT machinery to the lysosome membrane for internalizing ubiquitinated cargoes, and 3) determine the...
This $377,500 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research focused on merging bacteriophage biology with microbial glycobiology. The key objectives of this 5-year project (8/1/2025 - 5/31/2030) are to: 1) Explore the mechanisms used by Campylobacter jejuni phages to replace canonical DNA bases with non-canonical bases, including investigating a new...
This Project Grant award for $803,808 from the National Science Foundation's Biological Sciences (CFDA 47.074) program will support research at New York University (NYU) to investigate the evolution of membrane protein transporters. The research aims to determine how mutations in these proteins impact their dynamics, conformational states, and transport directionality, providing insights into membrane protein biogenesis. The project will involve training students and postdoctoral associates in...