The University of Georgia Research Foundation was awarded a $540,193 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The 12-month award, effective August 22, 2023, supports research to investigate the role of calcium-binding proteins and other secretory pathway components in the exocytosis of organelles critical for the invasion and egress of the malaria parasite Plasmodium falciparum...
This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
This $423,500.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of Utah to investigate the role of invariant natural killer T (iNKT) cells in shaping the immune response to Plasmodium infection, which can lead to the severe neurological condition of cerebral malaria. The research aims to define how the T cell receptor (TCR) signaling properties of different iNKT cell...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $244,440.00 to Albert Einstein College of Medicine to conduct research on the role of cytolytic ZEB2+ memory CD4+ T cells in protection against liver stage malaria. The research aims to gain insights into the cellular immune determinants associated with natural clinical immunity to malaria, in order to inform the development of more effective...
This Project Grant award of $375,000.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project to investigate the role of messenger ribonucleoprotein (mRNP) granules in regulating RNA metabolism and translation in the malaria parasite Plasmodium falciparum. The project aims to identify molecular markers for distinct mRNP types, determine their protein and mRNA compositions, and characterize their...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $445,488 to the University of Maryland, Baltimore to conduct research on the role of long non-coding RNAs (lncRNAs) in regulating gene expression in the malaria parasite Plasmodium falciparum. The key objectives are to: 1) Evaluate how lncRNAs influence the regulation of gene expression of neighboring and distant genes using computational...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $479,204 to the University of Maryland, Baltimore to conduct research on parasite variant surface antigens and their role in severe malaria. The research aims to identify parasite genes associated with severe disease, which could inform vaccine and drug development. Key aspects include: Sequencing variant surface antigen transcripts...
The federal Project Grant award of $459,131, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports research to identify essential functions of the mitochondrion in malaria parasites. The goal is to uncover novel drug targets within the parasite mitochondrion that could lead to the development of new antimalarial treatments effective against both symptomatic and transmission stages of malaria...
This Federal Project Grant award of $131,154 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research by Yale University to quantify functional immune responses against Plasmodium falciparum, the parasite that causes malaria. The research objectives are to: 1) Assess mechanisms of protective blood-stage immune responses, including neutralization and opsonic phagocytosis, and 2) Understand how merozoite antigenic...