Project Grant R21AI191916
- Federal Grant Award Summary Case Western Reserve University's Office of Research Administration received a $233,790 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 20, 2026, with completion by January 31, 2028. The award supports investigator-initiated biomedical research examining cytomegalovirus (CMV) reactivation in vascular tissues of people with HIV (PWH)...
- Federal Project Grant Award Summary Case Western Reserve University received a $354,570 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 7, 2025, with a completion date of June 30, 2030. The university will develop an innovative point-of-care diagnostic tool called CAMOchip for detecting HIV/Hepatitis B Virus (HBV) co-infection. The technology employs a microchip utilizing...
- Federal Project Grant Award Summary Case Western Reserve University's Office of Research Administration received a $121,003 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 15, 2025, with a completion date of June 30, 2027. The award supports structural biology research focused on characterizing platelet membrane proteins at the atomic level using advanced cryo-electron microscopy...
- Federal Grant Award Summary Case Western Reserve University received a $282,757 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026, through March 31, 2028. The award supports computational and experimental development of novel human monoclonal antibodies (MAbs) targeting Plasmodium vivax (PV), a parasitic pathogen responsible for malaria infections. The research...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $2,981,544 to the University of California, San Francisco under the Cardiovascular Diseases Research program (CFDA 93.837) on August 15, 2025, for a project examining the impact of asymptomatic cytomegalovirus (CMV) infection on cardiovascular event risk in people with HIV (PWH). This four-year project, extending through July 31, 2029, will conduct the largest Mendelian randomization study to date...
- Federal Grant Award Summary Case Western Reserve University received a $730,764 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 1, 2025, with completion targeted for March 31, 2029. The award supports research to elucidate the molecular basis of cardiac myosin binding protein C (CMYBP-C) hypertrophic cardiomyopathy (HCM) variants and their effects on cardiac function. The research will...
- Federal Project Grant Summary Award Details: Case Western Reserve University received a $109,076 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award was obligated on September 30, 2025, with an ultimate completion date of September 29, 2029, and will be performed at the university's Cleveland, Ohio location. Products and Services: The grant funds research aimed at improving cardiovascular risk...
- Federal Grant Award Summary Case Western Reserve University received a $813,450 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2030. The award supports longitudinal immunological research evaluating human T cell responses specific for Mycobacterium tuberculosis (MTB) antigens processed and presented by infected macrophages. The research...
- Federal Project Grant Award Summary Case Western Reserve University (CWRU) was awarded a Project Grant of $402,500 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, with a completion date of July 31, 2030. This NIGMS Maximizing Investigators' Research Award (MIRA) supports an early-stage investigator conducting research on heme-based immune dysregulation in critical illness. The grant will...
- Federal Grant Award Summary The University of California, San Francisco received a $3.26 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2029. This award funds comprehensive research investigating the mechanisms underlying sudden cardiac death (SCD) in people with HIV (PWH), with particular focus on immune activation and myocardial arrhythmic...
Case Western Reserve University received a $235,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 17, 2026 through March 31, 2028. The research initiative, conducted at the university's Cleveland, Ohio location in affiliation with University Hospitals of Cleveland, investigates plasma cell-free hemoglobin (CFH) as a potential driver of cardiovascular disease (CVD) risk in people with HIV (PWH). Despite effective antiretroviral treatment, PWH experience persistent low-grade inflammation, pro-active blood clotting mechanisms, and approximately twofold higher cardiovascular disease risk compared to non-HIV individuals—a gap inadequately explained by current understanding of CVD pathogenesis. The project delivers comprehensive scientific research examining red blood cell-derived extracellular vesicles (REVs) containing cell-free hemoglobin and their pathobiological significance in CVD risk. The study will characterize and quantify REVs, investigate their ability to trigger endothelial and platelet responses, and assess the impact of REV-associated cell-free hemoglobin on endothelial dysfunction and platelet activation. This research addresses a previously underappreciated CVD risk factor in PWH populations and aims to reveal novel translational approaches to mitigate endothelial dysfunction and chronic inflammation, thereby advancing scientific knowledge and informing therapeutic strategies for improved health outcomes in HIV-positive individuals.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $235.5k | 4/21/26 |