This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop novel antifungal agents against coccidioidomycosis, also known as Valley Fever. The overarching goal is to optimize the antifungal activity of synthetic analogs of a promising natural product candidate that has demonstrated potent fungicidal activity against Coccidioides in a murine model. The $2,917,725...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $112,539 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas at San Antonio (UTSA) to repurpose existing FDA-approved drugs as potential novel antifungal treatments for coccidioidomycosis, also known as Valley Fever. The project aims to investigate the synergistic effects of combining six repurposed drug candidates with the antifungal drug amphotericin B, in...
This National Science Foundation (NSF) Biological Sciences Program (CFDA 47.074) project grant in the amount of $240,000 will fund a postdoctoral research fellowship from July 1, 2024 to June 30, 2027. The research will investigate the environmental drivers of soil fungal pathogen spread, focusing on Coccidioides immitis, the pathogen that causes Valley Fever. The project aims to uncover the roles of landscape structure and local climate in shaping fungal pathogen distributions using genomic...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $442,470.00 to the University of California, Merced to investigate the role of regulatory T cells in controlling immune responses to Coccidioides infection, which causes Valley Fever. The research aims to define the mechanistic relationship between regulatory T cells and the body's ability to clear Coccidioides fungal infections, in order to improve diagnosis,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,797,623 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Regents of the University of California, San Francisco (UCSF) to conduct research aimed at understanding the significance of pathogen genetic variation and evolution. The grant, with a period of performance from July 2024 to May 2029, will utilize a combination of genetics and experimental evolution to investigate complex epistasis...
This Project Grant award of $642,775 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to accelerate the discovery of novel antifungal peptides using one-bead one-compound (OBOC) combinatorial technology. The primary objectives are to develop and optimize antifungal agents with broad-spectrum activity, diverse mechanisms of action, and high therapeutic indices. The research...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $170,000.00 to Prokaryotics Incorporated to conduct research focused on developing novel antifungal therapeutics. The research aims to perform structural elucidation of key fungal enzymes involved in glycosylphosphatidylinositol (GPI) biosynthesis, and use those insights to guide the synthesis and evaluation of new...
This $2,093,289 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to advance the genetic engineering and axenic growth of two tick-borne rickettsial pathogens, Ehrlichia chaffeensis and Anaplasma phagocytophilum. The research aims to: 1) Optimize HIMAR1 mutagenesis to develop a comprehensive mutational library for E. chaffeensis; 2) Expand targeted mutation...
The University of California, San Francisco (UCSF) received a $214,160 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of this 2-year award, with a completion date of November 30, 2026, is to evaluate the potential of leveraging the existing Seasonal Malaria Chemoprevention (SMC) platform in Burkina Faso to deliver co-interventions that may augment the efficacy of...
This $494,696 federal Project Grant award, made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to advance understanding of the translational control mechanisms that regulate the ability of the fungal pathogen Candida albicans to respond to host environmental stresses and undergo morphological transitions critical for virulence. The research will investigate how the C. albicans proteins ASC1 and...