This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $232,500.00 to investigate the role of the Rickettsia buchneri endosymbiont in protecting the blacklegged tick (Ixodes scapularis) against infection by pathogenic microbes. The key objectives are to: Analyze the regulation and expression of R. buchneri's putative antibiotic synthesis and toxin/antidote genes under...
This three-year, $856,682 project grant from the National Institute of Allergy and Infectious Diseases' Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at Pepperdine University integrating population genomics and microbial metagenomics of the lone star tick. The university will conduct three specific aims: 1) examine spatial genomic variation in lone star tick populations near western and northern range boundaries, hypothesizing a cline of diversity with climate...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,663,244.00 to characterize the innate immune signaling pathways in the tick Ixodes scapularis. The research aims to improve understanding of immune signaling in ticks, which are vectors of Lyme disease and other emerging diseases of growing health relevance in the U.S. and Europe. The project will combine...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $431,143 to support research aimed at developing methods for continuous in vitro propagation of the Babesia microti parasite. The key objectives are: (1) propagating B. microti within tick cell lines, (2) testing the capacity for B. microti to replicate in erythrocyte lysate substrates, and (3) using a...
This Project Grant award of $355,000 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop comprehensive tools for the identification of Hyalomma tick species that are vectors of Crimean-Congo Hemorrhagic Fever (CCHF) virus. The key objectives are to: 1) resolve the systematics of closely related Hyalomma species using morphological data and genomic analysis, and 2) produce...
This $300,000 Project Grant, awarded by the USDA's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (CFDA 10.310) program, will support the development of a sensitive, high-throughput multiplex diagnostic assay to simultaneously detect six major tick-borne pathogens, including Anaplasma, Borrelia, Ehrlichia, Rickettsia, Babesia, and Theileria. This assay will leverage barcoded magnetic bead technology to rapidly identify the causative agents of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to enhance the understanding of antibody-mediated immunity against Brucella infections. The $387,860 award, effective July 25, 2024 through June 30, 2026, will support research at the University of Missouri System to: 1) determine how vaccine-elicited antibodies alter tissue metabolism to restrict Brucella infections,...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of the FBB-1 bacteriophage in driving horizontal gene transfer between strains of the Borrelia burgdorferi spirochete, the causative agent of Lyme disease. The $2,014,302 award, with a period of performance from July 2024 to June 2029, aims to: 1) measure horizontal gene...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to investigate the evolution, fitness, and pathogenesis of Powassan virus (POWV) in the Northeast and Midwest United States. The total award amount is $749,411.00 for the period of July 1, 2024 to June 30, 2029. The key objectives of this project are to: 1) assess the distribution and genetic...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $250,573 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Pittsburgh to study how host genetic factors impact Babesia microti infection transmitted through ticks. The two-year research project (3/1/2025 - 2/28/2027) will leverage the Collaborative Cross mouse resource to: Test the hypothesis that host genetic polymorphisms significantly impact parasitemia levels, infection...