This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to develop an mRNA vaccination targeting Amblyomma ticks to prevent alpha-gal syndrome. The $251,250 award to Yale University, effective February 1, 2025 through January 31, 2027, will support research to determine if acquired tick resistance (ATR) can be induced against the Amblyomma americanum tick, which is associated with IgE-mediated...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,663,244 project grant under CFDA 93.855, Allergy and Infectious Diseases Research, to President and Fellows of Harvard College (Harvard Medical School) on March 1, 2025. The project aims to characterize innate immune signaling pathways in the tick Ixodes scapularis, which is a vector for Lyme disease and other emerging infectious diseases. The research will combine cell culture-based methods with in vivo assays in...
This $225,953 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research aims to define the characteristics of human B cells that specifically target foreign glycans, known as xenoglycans. The funded research will use antigen-specific tetramers to identify and isolate distinct populations of xenoglycan-reactive B cells and compare their phenotypic and functional properties to protein-reactive B cells....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $518,099 to the University of Maryland, College Park to investigate a cross-species signaling system in tick immunity and development. The research aims to define how interactions between a novel tick protein (ISCDL) and the tick cell surface receptor DOME1 impact tick immune responses and development, either...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $423,106 over a 2-year period starting August 1, 2025 to characterize the roles of tick inhibitors of metalloproteases in the transmission of the Lyme disease agent by blacklegged ticks. The research aims to unveil the protease inhibition profiles of these tick proteins and elucidate their impacts on Lyme...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $461,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant, effective July 1, 2025 through June 30, 2027, will fund a project to systematically identify interactions between Lyme disease bacteria (Borrelia burgdorferi) and the extracellular, secreted, and transmembrane proteins of its tick vector, Ixodes scapularis. The project aims to develop a...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $220,096 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Michigan State University. The objective of this 2-year project, which runs from November 2024 to October 2026, is to elucidate the mechanisms of tetrodotoxin (TTX) biosynthesis in microbial symbionts. The researchers plan to leverage their discovery of TTX-producing bacteria on newt skin to sequence bacterial genomes,...
This $165,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of an improved transposon mutagenesis system for comprehensive genetic analysis of Borrelia burgdorferi, the bacterium that causes Lyme disease. The project aims to create a high-efficiency transposon insertional mutagenesis system and employ transposon sequencing techniques to conduct...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...