This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $518,099 to the University of Maryland, College Park to investigate a cross-species signaling system in tick immunity and development. The research aims to define how interactions between a novel tick protein (ISCDL) and the tick cell surface receptor DOME1 impact tick immune responses and development, either...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $461,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant, effective July 1, 2025 through June 30, 2027, will fund a project to systematically identify interactions between Lyme disease bacteria (Borrelia burgdorferi) and the extracellular, secreted, and transmembrane proteins of its tick vector, Ixodes scapularis. The project aims to develop a...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,663,244 project grant under CFDA 93.855, Allergy and Infectious Diseases Research, to President and Fellows of Harvard College (Harvard Medical School) on March 1, 2025. The project aims to characterize innate immune signaling pathways in the tick Ixodes scapularis, which is a vector for Lyme disease and other emerging infectious diseases. The research will combine cell culture-based methods with in vivo assays in...
This $165,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of an improved transposon mutagenesis system for comprehensive genetic analysis of Borrelia burgdorferi, the bacterium that causes Lyme disease. The project aims to create a high-efficiency transposon insertional mutagenesis system and employ transposon sequencing techniques to conduct...
The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $191,250 to Washington State University (WSU) to conduct research on the immune evasion mechanism of the Lyme disease spirochete, Borrelia burgdorferi. The award supports mechanistic studies on the role of genetic factors in the antigenic variation of the VlsE surface protein, a key mechanism for persistent...
This Project Grant award of $509,130 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of South Florida to investigate the global virulence regulatory network of the Lyme disease pathogen Borrelia burgdorferi. The key objectives are to: 1) Define the BosR regulon and characterize how BosR-regulated genes contribute to the infectious cycle of B. burgdorferi; 2) Examine the biological roles of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate the role of a tick endosymbiont, Rickettsia buchneri, in preventing tick-borne pathogens from infecting the blacklegged tick, Ixodes scapularis. The $232,500 award to the Regents of the University of Minnesota will fund two main research aims: 1) analyzing the regulation and expression of R....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $242,185 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M Agrilife Research. The grant supports research to investigate the role of RNA structure in regulating developmental RNA editing in pathogenic trypanosomes, such as Trypanosoma brucei. The key objectives are to: 1) Develop a new technique to assess RNA structure under native cellular conditions versus in vitro,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to develop an mRNA vaccination targeting Amblyomma ticks to prevent alpha-gal syndrome. The $251,250 award to Yale University, effective February 1, 2025 through January 31, 2027, will support research to determine if acquired tick resistance (ATR) can be induced against the Amblyomma americanum tick, which is associated with IgE-mediated...