Project Grant R21AI190938

Award Date 7/24/25
Completion Date 6/30/27
Dollars Obligated $422K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Texas, USA
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The goal is to identify signature genomic regions of antimicrobial resistant pathogens that can be specifically detected in wastewater, enabling more actionable antimicrobial resistance monitoring. This includes developing a genomic language model approach to pinpoint conserved pathogen regions, integrated with an automated assay design pipeline. On the wet lab side, the university will use microdroplet encapsulation to isolate and enrich antimicrobial resistant bacteria from wastewater for digital PCR testing of the signature regions. The resulting software, assays, and protocols will be made publicly available to support antimicrobial resistance surveillance by public health labs and wastewater programs.

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