Project Grant R21AI190856
Award Date
1/10/25
Completion Date
12/31/26
Dollars Obligated
$236K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Georgia, USA
Similar Awards
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop a single-cell resolution understanding of pathogenesis and antibiotic tolerance in Staphylococcus aureus. The $312,000 award, spanning from September 1, 2024 to August 31, 2026, will enable the University of Texas Health Science Center at Houston to explore the relationship between...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $565,149 to Health Research, Inc. Wadsworth Center Division to conduct research on RNA-based regulatory mechanisms in Mycobacterium tuberculosis (MTB). The primary objectives are to: Define the regulatory interactions of the sRNA MCR11 and its impact on gene expression in MTB. Characterize the roles of RNA-ABMR...
This $849,713 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to elucidate RNA-RNA interaction networks during interbacterial interactions involving the bacterium Pseudomonas aeruginosa. The research team at Boston Children's Hospital seeks to define the small RNA (sRNA) interaction network in P. aeruginosa and decode the regulatory roles played by sRNAs during its interactions with other bacteria. The project will...
This federal Project Grant award under the National Institute of Allergy and Infectious Diseases' (NIAID) Allergy and Infectious Diseases Research program (CFDA 93.855) provides $453,621.00 to Georgia Tech Research Corp to study how changes in the lipopolysaccharide (LPS) composition of the bacterium Pseudomonas aeruginosa influence its aggregate formation and social behaviors. The key objectives are to: (I) determine changes in frequency of P. aeruginosa isolates with differential LPS structure...
The University of Chicago received a $918,400 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), to identify protective antigens and immune responses against Staphylococcus aureus. The objective is to exploit the observation that mice lacking the H2-O protein, which negatively regulates MHC-II antigen presentation, are able to efficiently decolonize S. aureus and resist...
This $637,275 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to uncover the mechanisms by which gram-negative bacterial pathogens develop rapid stress tolerance to chemical stressors, such as antibiotics. The research will focus on understanding how bacteria can adaptively restrict the intracellular accumulation of drugs by inhibiting the functioning of...
This federal Project Grant award, valued at $453,900.00 and granted by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a genome editing platform leveraging phage recombinases. The project aims to create a broadly applicable bacterial genetic engineering system capable of operating across a wide range of Gram-positive and Gram-negative species, including clinically relevant...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $189,558 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Duke University to study the genomic determinants of antibiotic treatment failure in Staphylococcus aureus bacteremia (SAB). The key objectives are to: 1) Identify bacterial genotypes associated with SAB antibiotic treatment failure using a murine in-vivo evolution model, and 2) Identify new bacterial genotypes associated with SAB...
This $1,003,736 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to expand the understanding of post-transcriptional regulation of gene expression in bacteria. The research will focus on two key areas: 1) Epitranscriptomic regulation of gene expression across the prokaryotic domain, examining RNA modifications and their regulatory roles, and 2) Post-transcriptional gene regulation via novel...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $390,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, titled "The Molecular Basis of Staphylococcus aureus SplB Manipulation of the Host", will fund a 5-year research project to identify host protein targets of the S. aureus SplB protease, elucidate the...