Project Grant R21AI190832
- This Project Grant award of $233,528 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, supports a systems analysis of immune responses to norovirus infection in a human challenge model. The research aims to delineate the transcriptomic responses in human peripheral blood and stool samples collected from volunteers before and after controlled infection with different strains and doses of norovirus. The goal is to...
- This $2,920,356 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the role of norovirus capsid dynamics in enabling immune evasion. The project aims to leverage the highly tractable mouse norovirus system to elucidate the structural changes and host metabolite interactions that allow the virus to switch between antibody-recognized and...
- This Project Grant award of $458,250.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a VP4-based pseudovirus nanoparticle rotavirus vaccine for oral immunization. The award will fund research to create a non-replicating rotavirus vaccine candidate called S-VP4E, which consists of a calicivirus inner shell and multiple rotavirus spikes (VP4E) on the surface. This...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, awarded a $192,260 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant will fund research to characterize the systemic and mucosal immune response to adenovirus 40/41 infection in Bangladeshi children and determine the efficacy of breast milk antibodies in providing...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on July 24, 2025. The grant will fund structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2, the virus that causes COVID-19. The goal is to determine the high-resolution structure of the full-length N protein in complex...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop novel multivalent mucosal vaccines for human noroviruses. The total funding is $798,173 with a project period from May 1, 2025 to April 30, 2030. The key products and services to be delivered include: 1) Developing multivalent, live-vectored mucosal norovirus vaccines using FDA-approved rotavirus (RotaTeq)...
- This $251,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support a clinical trial planning project focused on evaluating the use of adeno-associated virus (AAV)-delivered broadly neutralizing antibodies (bnAbs) to achieve durable control of HIV-1 in children after discontinuation of antiretroviral therapy (ART). The award to the University of Massachusetts Medical School will help develop a full...
- This $128,461 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to determine the role of antibody epitope specificity in regulating Fc effector functions against SARS-CoV-2 and other viral pathogens. The research aims to integrate deep mutational scanning into systems serology to map the epitope specificities within IgG subclass and FcγR binding...
- This Project Grant award of $156,080 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The award supports research to uncover the underlying biology and key properties that define "broadly neutralizing" antibodies - those that can recognize and neutralize a wide range of related pathogens. Using SARS-CoV-2 as a model, the research aims to determine whether the...
- This $433,125 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Ohio State University aims to investigate the use of a novel oral adjuvant to enhance natural killer (NK) cell cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC) activity in the nonhuman primate model. The research seeks to discover a novel vaccine adjuvant that strengthens NK cell activity against SIV/HIV in different...
This $427,625 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program aims to characterize the kinetics of neutralizing antibodies to sapovirus (SAV) in a longitudinal study of 50 children in Nicaragua experiencing SAV gastroenteritis episodes. The researchers will test whether polyclonal sera can neutralize homotypic and heterotypic SAV strains, and compare neutralizing antibody levels between children who do and do not develop SAV acute gastroenteritis. The project will also determine the correlation between neutralizing antibody levels and levels of other antibody types. This research seeks to advance the understanding of natural immunity to SAV in order to guide future vaccine development efforts against this important cause of childhood gastroenteritis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 9/9/25 |